Prostaglandin-generating factor of anaphylaxis induces mucous glycoprotein release and the formation of lipoxygenase products of arachidonate from human airways

Z. Marom; J. H. Shelhamer; L. Steel; E. J. Goetzl; M. Kaliner

doi:10.1016/0090-6980(84)90115-1

Prostaglandin-generating factor of anaphylaxis induces mucous glycoprotein release and the formation of lipoxygenase products of arachidonate from human airways

Z. Marom
, J. H. Shelhamer
, L. Steel
, E. J. Goetzl
, M. Kaliner

Research output: Contribution to journal › Article › peer-review

11 Scopus citations

Abstract

The effects of prostaglandin-generating factor of anaphylaxis (PGF-A) upon the lipoxygenaton of arachidonic acid and the promotion of mucous glycoprotein secretion by human airways were analyzed concurrently in order to determine the role that lipoxygenase products play in the secretion of mucus which accompanies immediate hypersensitivity reactions of airways. PGF-A enhanced both mucous glycoprotein relesae and the 5- and 15-lipoxygenation of arachidonic acid as well as the formation of leukotrien B₄ (LTB₄) with similar dose-response relationships. The capacity of PGF-A to stimulate mucous glycoprotein release was inhibited by ETYA but not by indomethacin, suggesting that PGF-A stimulated lipoxygenase products may be involved. Lipoxygenase products of arachidonic acid thus may serve as mediators of the enhancement of mucus secretion from human airways in response to PGF-A.

Original language	English
Pages (from-to)	79-91
Number of pages	13
Journal	Prostaglandins
Volume	28
Issue number	1
DOIs	https://doi.org/10.1016/0090-6980(84)90115-1
State	Published - Jul 1984
Externally published	Yes

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@article{a4732895420b4a08a5a8faa4099ce318,

title = "Prostaglandin-generating factor of anaphylaxis induces mucous glycoprotein release and the formation of lipoxygenase products of arachidonate from human airways",

abstract = "The effects of prostaglandin-generating factor of anaphylaxis (PGF-A) upon the lipoxygenaton of arachidonic acid and the promotion of mucous glycoprotein secretion by human airways were analyzed concurrently in order to determine the role that lipoxygenase products play in the secretion of mucus which accompanies immediate hypersensitivity reactions of airways. PGF-A enhanced both mucous glycoprotein relesae and the 5- and 15-lipoxygenation of arachidonic acid as well as the formation of leukotrien B4 (LTB4) with similar dose-response relationships. The capacity of PGF-A to stimulate mucous glycoprotein release was inhibited by ETYA but not by indomethacin, suggesting that PGF-A stimulated lipoxygenase products may be involved. Lipoxygenase products of arachidonic acid thus may serve as mediators of the enhancement of mucus secretion from human airways in response to PGF-A.",

author = "Z. Marom and Shelhamer, \{J. H.\} and L. Steel and Goetzl, \{E. J.\} and M. Kaliner",

note = "Funding Information: The authors thank S. Starnes for manuscript preparation and K. Leighty for editorial assistance, and gratefully acknowledge the cooperation of the Pathology and Surgery Departments of the Washington Hospital Center, Sibley Hospital, Suburban Hospital, Walter Reed Army Medical Center, Holy Cross Hospital, Washington Adventist Hospital and Montgomery General Hospital for their help in providing surgical specimens for these studies. This work was partly supported by a grant from the Heart, Lung and Blood Institute (HL06142-02) and in part by the National Research Service Award (SF32).",

year = "1984",

month = jul,

doi = "10.1016/0090-6980(84)90115-1",

language = "English",

volume = "28",

pages = "79--91",

journal = "Prostaglandins",

issn = "0090-6980",

publisher = "Elsevier B.V.",

number = "1",

}

TY - JOUR

T1 - Prostaglandin-generating factor of anaphylaxis induces mucous glycoprotein release and the formation of lipoxygenase products of arachidonate from human airways

AU - Marom, Z.

AU - Shelhamer, J. H.

AU - Steel, L.

AU - Goetzl, E. J.

AU - Kaliner, M.

N1 - Funding Information: The authors thank S. Starnes for manuscript preparation and K. Leighty for editorial assistance, and gratefully acknowledge the cooperation of the Pathology and Surgery Departments of the Washington Hospital Center, Sibley Hospital, Suburban Hospital, Walter Reed Army Medical Center, Holy Cross Hospital, Washington Adventist Hospital and Montgomery General Hospital for their help in providing surgical specimens for these studies. This work was partly supported by a grant from the Heart, Lung and Blood Institute (HL06142-02) and in part by the National Research Service Award (SF32).

PY - 1984/7

Y1 - 1984/7

N2 - The effects of prostaglandin-generating factor of anaphylaxis (PGF-A) upon the lipoxygenaton of arachidonic acid and the promotion of mucous glycoprotein secretion by human airways were analyzed concurrently in order to determine the role that lipoxygenase products play in the secretion of mucus which accompanies immediate hypersensitivity reactions of airways. PGF-A enhanced both mucous glycoprotein relesae and the 5- and 15-lipoxygenation of arachidonic acid as well as the formation of leukotrien B4 (LTB4) with similar dose-response relationships. The capacity of PGF-A to stimulate mucous glycoprotein release was inhibited by ETYA but not by indomethacin, suggesting that PGF-A stimulated lipoxygenase products may be involved. Lipoxygenase products of arachidonic acid thus may serve as mediators of the enhancement of mucus secretion from human airways in response to PGF-A.

AB - The effects of prostaglandin-generating factor of anaphylaxis (PGF-A) upon the lipoxygenaton of arachidonic acid and the promotion of mucous glycoprotein secretion by human airways were analyzed concurrently in order to determine the role that lipoxygenase products play in the secretion of mucus which accompanies immediate hypersensitivity reactions of airways. PGF-A enhanced both mucous glycoprotein relesae and the 5- and 15-lipoxygenation of arachidonic acid as well as the formation of leukotrien B4 (LTB4) with similar dose-response relationships. The capacity of PGF-A to stimulate mucous glycoprotein release was inhibited by ETYA but not by indomethacin, suggesting that PGF-A stimulated lipoxygenase products may be involved. Lipoxygenase products of arachidonic acid thus may serve as mediators of the enhancement of mucus secretion from human airways in response to PGF-A.

UR - https://www.scopus.com/pages/publications/0021240138

U2 - 10.1016/0090-6980(84)90115-1

DO - 10.1016/0090-6980(84)90115-1

M3 - Article

C2 - 6091187

AN - SCOPUS:0021240138

SN - 0090-6980

VL - 28

SP - 79

EP - 91

JO - Prostaglandins

JF - Prostaglandins

IS - 1

ER -

Prostaglandin-generating factor of anaphylaxis induces mucous glycoprotein release and the formation of lipoxygenase products of arachidonate from human airways

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