Prostaglandin-generating factor of anaphylaxis induces mucous glycoprotein release and the formation of lipoxygenase products of arachidonate from human airways

Z. Marom, J. H. Shelhamer, L. Steel, E. J. Goetzl, M. Kaliner

Research output: Contribution to journalArticlepeer-review

11 Scopus citations

Abstract

The effects of prostaglandin-generating factor of anaphylaxis (PGF-A) upon the lipoxygenaton of arachidonic acid and the promotion of mucous glycoprotein secretion by human airways were analyzed concurrently in order to determine the role that lipoxygenase products play in the secretion of mucus which accompanies immediate hypersensitivity reactions of airways. PGF-A enhanced both mucous glycoprotein relesae and the 5- and 15-lipoxygenation of arachidonic acid as well as the formation of leukotrien B4 (LTB4) with similar dose-response relationships. The capacity of PGF-A to stimulate mucous glycoprotein release was inhibited by ETYA but not by indomethacin, suggesting that PGF-A stimulated lipoxygenase products may be involved. Lipoxygenase products of arachidonic acid thus may serve as mediators of the enhancement of mucus secretion from human airways in response to PGF-A.

Original languageEnglish
Pages (from-to)79-91
Number of pages13
JournalProstaglandins
Volume28
Issue number1
DOIs
StatePublished - Jul 1984
Externally publishedYes

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