Prospects for clinical applications of butyrate-producing bacteria

Li Bin Zhu, Yu Chen Zhang, Han Hui Huang, Jing Lin

Research output: Contribution to journalReview articlepeer-review

11 Scopus citations


As the major source of energy for colonic mucosal cells and as an important regulator of gene expression, inflammation, differentiation, and apoptosis in host cells, microbiota-derived butyrate can enhance the intestinal mucosal immune barrier, modulate systemic immune response, and prevent infections. Maintaining a certain level of butyrate production in the gut can help balance intestinal microbiota, regulate host immune response, and promote the development and maintenance of the intestinal mucosal barrier. Butyrate-producing bacteria act as probiotics and play important roles in a variety of normal biological functions. Bacteriotherapeutic supplementation by using fecal microbiota transplantation to restore butyrate-producing commensal bacteria in the gut has been very successful in the treatment of recurrent and refractory Clostridium difficile (C. difficile) infection or C. difficile-negative nosocomial diarrhea. Administration of probiotics that include butyrate-producing bacteria may have a role in the treatment of inflammatory bowel diseases and in the prevention of necrotizing enterocolitis and late-onset sepsis in premature infants. Furthermore, modulating gut microbiota with dietary approaches may improve intestinal dysbiosis commonly seen in patients with obesity-associated metabolic disorders. Supplementation with a butyrate-producing bacterial stain might be used to increase energy expenditure, improve insulin sensitivity, and to help control obesity and metabolic syndrome.

Original languageEnglish
Pages (from-to)84-92
Number of pages9
JournalWorld Journal of Clinical Pediatrics
Issue number5
StatePublished - Sep 2021


  • Butyrate
  • Butyrate-producing bacteria
  • Gut microbiota
  • Intestinal mucosal barrier
  • Metabolic syndrome
  • Probiotics


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