TY - JOUR
T1 - Prospective Endoscopic Activity Assessment for Eosinophilic Gastritis in a Multisite Cohort
AU - CEGIR investigators
AU - Hirano, Ikuo
AU - Collins, Margaret H.
AU - King, Eileen
AU - Sun, Qin
AU - Chehade, Mirna
AU - Abonia, J. Pablo
AU - Bonis, Peter A.
AU - Capocelli, Kelly E.
AU - Dellon, Evan S.
AU - Falk, Gary W.
AU - Gonsalves, Nirmala
AU - Gupta, Sandeep K.
AU - Leung, John
AU - Katzka, David
AU - Menard-Katcher, Paul
AU - Khoury, Paneez
AU - Klion, Amy
AU - Mukkada, Vincent A.
AU - Peterson, Kathryn
AU - Shoda, Tetsuo
AU - Rudman-Spergel, Amanda K.
AU - Spergel, Jonathan A.
AU - Yang, Guang Yu
AU - Rothenberg, Marc E.
AU - Aceves, Seema S.
AU - Furuta, Glenn T.
N1 - Publisher Copyright:
Copyright © 2022 by The American College of Gastroenterology.
PY - 2022/3/1
Y1 - 2022/3/1
N2 - INTRODUCTION: Eosinophilic gastritis (EG) is a chronic inflammatory disease of the stomach characterized by eosinophil-predominant gastric mucosal inflammation and gastrointestinal symptoms. The aim of this study was to prospectively evaluate endoscopic features in a large series of children and adults with EG to better understand the endoscopic manifestations and develop a standardized instrument for investigations. METHODS: Data were prospectively collected as part of the Consortium for Eosinophilic Gastrointestinal Disease Researchers, a national collaborative network. Endoscopic features were prospectively recorded using a system specifically developed for EG, the EG Endoscopic Reference System (EG-REFS). Correlations were made between EG-REFS and clinical and histologic features. RESULTS: Of 98 patients with EG, 65 underwent assessments using EG-REFS. The most common findings were erythema (72%), raised lesions (49%), erosions (46%), and granularity (35%); only 8% of patients with active histology (≥30 eosinophils/high-power field) exhibited no endoscopic findings. A strong correlation between EG-REFS scores and physician global assessment of endoscopy severity was demonstrated (Spearman r = 0.84, P < 0.0001). The overall score and specific components of EG-REFS were more common in the antrum than in the fundus or body. EG-REFS severity was significantly correlated with active histology, defined by a threshold of ≥30 eosinophils/high-power field (P = 0.0002). DISCUSSION: Prospective application of EG-REFS identified gastric features with a strong correlation with physician global assessment of endoscopic activity in EG. Endoscopic features demonstrated greater severity in patients with active histology and a predilection for the gastric antrum. Further development of EG-REFS should improve its utility in clinical studies.
AB - INTRODUCTION: Eosinophilic gastritis (EG) is a chronic inflammatory disease of the stomach characterized by eosinophil-predominant gastric mucosal inflammation and gastrointestinal symptoms. The aim of this study was to prospectively evaluate endoscopic features in a large series of children and adults with EG to better understand the endoscopic manifestations and develop a standardized instrument for investigations. METHODS: Data were prospectively collected as part of the Consortium for Eosinophilic Gastrointestinal Disease Researchers, a national collaborative network. Endoscopic features were prospectively recorded using a system specifically developed for EG, the EG Endoscopic Reference System (EG-REFS). Correlations were made between EG-REFS and clinical and histologic features. RESULTS: Of 98 patients with EG, 65 underwent assessments using EG-REFS. The most common findings were erythema (72%), raised lesions (49%), erosions (46%), and granularity (35%); only 8% of patients with active histology (≥30 eosinophils/high-power field) exhibited no endoscopic findings. A strong correlation between EG-REFS scores and physician global assessment of endoscopy severity was demonstrated (Spearman r = 0.84, P < 0.0001). The overall score and specific components of EG-REFS were more common in the antrum than in the fundus or body. EG-REFS severity was significantly correlated with active histology, defined by a threshold of ≥30 eosinophils/high-power field (P = 0.0002). DISCUSSION: Prospective application of EG-REFS identified gastric features with a strong correlation with physician global assessment of endoscopic activity in EG. Endoscopic features demonstrated greater severity in patients with active histology and a predilection for the gastric antrum. Further development of EG-REFS should improve its utility in clinical studies.
UR - http://www.scopus.com/inward/record.url?scp=85125683152&partnerID=8YFLogxK
U2 - 10.14309/ajg.0000000000001625
DO - 10.14309/ajg.0000000000001625
M3 - Article
C2 - 35080202
AN - SCOPUS:85125683152
SN - 0002-9270
VL - 117
SP - 413
EP - 423
JO - American Journal of Gastroenterology
JF - American Journal of Gastroenterology
IS - 3
ER -