TY - JOUR
T1 - Prospective Endoscopic Activity Assessment for Eosinophilic Gastritis in a Multisite Cohort
AU - CEGIR investigators
AU - Hirano, Ikuo
AU - Collins, Margaret H.
AU - King, Eileen
AU - Sun, Qin
AU - Chehade, Mirna
AU - Abonia, J. Pablo
AU - Bonis, Peter A.
AU - Capocelli, Kelly E.
AU - Dellon, Evan S.
AU - Falk, Gary W.
AU - Gonsalves, Nirmala
AU - Gupta, Sandeep K.
AU - Leung, John
AU - Katzka, David
AU - Menard-Katcher, Paul
AU - Khoury, Paneez
AU - Klion, Amy
AU - Mukkada, Vincent A.
AU - Peterson, Kathryn
AU - Shoda, Tetsuo
AU - Rudman-Spergel, Amanda K.
AU - Spergel, Jonathan A.
AU - Yang, Guang Yu
AU - Rothenberg, Marc E.
AU - Aceves, Seema S.
AU - Furuta, Glenn T.
N1 - Funding Information:
Financial support for this project was provided by the Analgesic, Anesthetic, and Addiction Clinical Trial Translations, Innovations, Opportunities, and Networks (ACTTION) public– private partnership, which has received research contracts (HHSF2232014001991C), grants, or other revenue from the U.S. Food and Drug Administration, multiple pharmaceutical and device companies, and other sources.
Publisher Copyright:
Copyright © 2022 by The American College of Gastroenterology.
PY - 2022/3/1
Y1 - 2022/3/1
N2 - INTRODUCTION: Eosinophilic gastritis (EG) is a chronic inflammatory disease of the stomach characterized by eosinophil-predominant gastric mucosal inflammation and gastrointestinal symptoms. The aim of this study was to prospectively evaluate endoscopic features in a large series of children and adults with EG to better understand the endoscopic manifestations and develop a standardized instrument for investigations. METHODS: Data were prospectively collected as part of the Consortium for Eosinophilic Gastrointestinal Disease Researchers, a national collaborative network. Endoscopic features were prospectively recorded using a system specifically developed for EG, the EG Endoscopic Reference System (EG-REFS). Correlations were made between EG-REFS and clinical and histologic features. RESULTS: Of 98 patients with EG, 65 underwent assessments using EG-REFS. The most common findings were erythema (72%), raised lesions (49%), erosions (46%), and granularity (35%); only 8% of patients with active histology (≥30 eosinophils/high-power field) exhibited no endoscopic findings. A strong correlation between EG-REFS scores and physician global assessment of endoscopy severity was demonstrated (Spearman r = 0.84, P < 0.0001). The overall score and specific components of EG-REFS were more common in the antrum than in the fundus or body. EG-REFS severity was significantly correlated with active histology, defined by a threshold of ≥30 eosinophils/high-power field (P = 0.0002). DISCUSSION: Prospective application of EG-REFS identified gastric features with a strong correlation with physician global assessment of endoscopic activity in EG. Endoscopic features demonstrated greater severity in patients with active histology and a predilection for the gastric antrum. Further development of EG-REFS should improve its utility in clinical studies.
AB - INTRODUCTION: Eosinophilic gastritis (EG) is a chronic inflammatory disease of the stomach characterized by eosinophil-predominant gastric mucosal inflammation and gastrointestinal symptoms. The aim of this study was to prospectively evaluate endoscopic features in a large series of children and adults with EG to better understand the endoscopic manifestations and develop a standardized instrument for investigations. METHODS: Data were prospectively collected as part of the Consortium for Eosinophilic Gastrointestinal Disease Researchers, a national collaborative network. Endoscopic features were prospectively recorded using a system specifically developed for EG, the EG Endoscopic Reference System (EG-REFS). Correlations were made between EG-REFS and clinical and histologic features. RESULTS: Of 98 patients with EG, 65 underwent assessments using EG-REFS. The most common findings were erythema (72%), raised lesions (49%), erosions (46%), and granularity (35%); only 8% of patients with active histology (≥30 eosinophils/high-power field) exhibited no endoscopic findings. A strong correlation between EG-REFS scores and physician global assessment of endoscopy severity was demonstrated (Spearman r = 0.84, P < 0.0001). The overall score and specific components of EG-REFS were more common in the antrum than in the fundus or body. EG-REFS severity was significantly correlated with active histology, defined by a threshold of ≥30 eosinophils/high-power field (P = 0.0002). DISCUSSION: Prospective application of EG-REFS identified gastric features with a strong correlation with physician global assessment of endoscopic activity in EG. Endoscopic features demonstrated greater severity in patients with active histology and a predilection for the gastric antrum. Further development of EG-REFS should improve its utility in clinical studies.
UR - http://www.scopus.com/inward/record.url?scp=85125683152&partnerID=8YFLogxK
U2 - 10.14309/ajg.0000000000001625
DO - 10.14309/ajg.0000000000001625
M3 - Article
C2 - 35080202
AN - SCOPUS:85125683152
SN - 0002-9270
VL - 117
SP - 413
EP - 423
JO - American Journal of Gastroenterology
JF - American Journal of Gastroenterology
IS - 3
ER -