Prospective comparison of patient characteristics and outcome of non-prior aspirin users versus aspirin users with unstable angina or non-Q-wave myocardial infarction treated with combination antithrombotic therapy

Marc Cohen, Philip C. Adams, Ruth McBride, Heiner Blanke, Valentin Fuster

Research output: Contribution to journalArticlepeer-review

14 Scopus citations

Abstract

The objective of this study was to determine if aspirin users presenting with acute coronary syndromes are at higher risk for subsequent clinical events. In a trial evaluating combination antithrombotic therapy in resting angina or non-and-wave myocardial infarction (MI), patients were prospectively dichotomized on admission into nonprior versus recent aspirin users. Then 105 nonprior users and 144 users were randomized to treatment with aspirin plus heparin/warfarin for 12 weeks. Recurrent myocardial ischemia occurring during the 12-week follow-up period was defined as recurrent angina (with electrocardiographic changes or prompting coronary revascularization), MI, or death. Prior aspirin users had a significantly higher incidence of previous MI, prior bypass grafting, beta-blocker use, or hypertension (p ≤ 0.003) and were more likely to present with unstable angina as opposed to non-and-wave MI. (p ≤ 0.008). The cumulative probability of recurrent ischemic endpoints for nonprior versus recent users was 10% versus 21% at 14 days (log rank p = 0.03), and 19% versus 29%, at 12 weeks (p = 0.06). Using the Cox model, adjusting for variables significantly associated with outcome, aspirin use remained a significant predictor of 14-day outcome (p = 0.04) but not of 12-week outcome (p = 0.06). In conclusion, even after adjusting for significant differences in baseline variables, aspirin users presenting with rest angina or non-Q-infarction have a worse short-term prognosis in spite of maximal medical therapy.

Original languageEnglish
Pages (from-to)275-280
Number of pages6
JournalJournal of Thrombosis and Thrombolysis
Volume4
Issue number2
DOIs
StatePublished - 1997

Keywords

  • Aspirin
  • Myocardial infarction
  • Non-Q-wave
  • Unstable angina

Fingerprint

Dive into the research topics of 'Prospective comparison of patient characteristics and outcome of non-prior aspirin users versus aspirin users with unstable angina or non-Q-wave myocardial infarction treated with combination antithrombotic therapy'. Together they form a unique fingerprint.

Cite this