TY - JOUR
T1 - Prospective 2-Year Course and Predictors of Outcome in Avoidant/Restrictive Food Intake Disorder
AU - Kambanis, P. Evelyna
AU - Tabri, Nassim
AU - McPherson, Iman
AU - Gydus, Julia E.
AU - Kuhnle, Megan
AU - Stern, Casey M.
AU - Asanza, Elisa
AU - Becker, Kendra R.
AU - Breithaupt, Lauren
AU - Freizinger, Melissa
AU - Shrier, Lydia A.
AU - Bern, Elana M.
AU - Eddy, Kamryn T.
AU - Misra, Madhusmita
AU - Micali, Nadia
AU - Lawson, Elizabeth A.
AU - Thomas, Jennifer J.
N1 - Publisher Copyright:
© 2024
PY - 2024
Y1 - 2024
N2 - Objective: To evaluate the 2-year course and outcomes of full and subthreshold avoidant/restrictive food intake disorder (ARFID) in youth aged 9 to 23 years at baseline using a prospective longitudinal design to characterize the remission and persistence of ARFID, evaluate diagnostic crossover, and identify predictors of outcome. Greater severity in each ARFID profile—sensory sensitivity, fear of aversive consequences, and lack of interest—was hypothesized to predict greater likelihood of illness persistence, controlling for age, sex, body mass index percentile, ARFID treatment status, and baseline diagnosis. Method: Participants (N = 100; age range, 9-23 years; 49% female; 91% White) were followed over 2 years. The Pica, ARFID, and Rumination Disorder Interview was used across 3 time points (baseline, year 1, year 2) to measure the severity of each ARFID profile and evaluate illness persistence or remission, and the Eating Disorder Assessment for DSM-5 was used to evaluate diagnostic crossover. Results: Across the 2-year follow-up period, half the participants persisted with their original diagnosis, and 3% of participants experienced a diagnostic shift to anorexia nervosa. Greater severity in the sensory sensitivity and lack of interest profiles was associated with higher likelihood of ARFID persistence at year 1 only; greater severity in the fear of aversive consequences profile was associated with higher likelihood of ARFID remission at year 2 only. Conclusion: Findings underscore the distinctiveness of ARFID from other eating disorders and emphasize its persistence over 2 years. Results also highlight the predictive validity and prognostic value of the ARFID profiles (ie, sensory sensitivity, fear of aversive consequences, lack of interest). Plain language summary: In this longitudinal study, the authors examined the course and outcomes of avoidant/restrictive food intake disorder (ARFID) in a sample of 100 youth aged 9 to 23 years over the course of 2 years. Across the 2-year follow-up period, half the sample persisted with their original diagnosis, and 3% of participants developed anorexia nervosa. Results indicate that profiles of greater sensory sensitivity to food and lack of interest in food/eating were associated with higher likelihood of ARFID persistence at year 1 only, whereas greater severity in the fear of aversive consequences of eating was associated with higher likelihood of ARFID remission at year 2 only. These findings highlight the persistence of ARFID and suggest that outcomes may vary depending on an individual's ARFID presentation.
AB - Objective: To evaluate the 2-year course and outcomes of full and subthreshold avoidant/restrictive food intake disorder (ARFID) in youth aged 9 to 23 years at baseline using a prospective longitudinal design to characterize the remission and persistence of ARFID, evaluate diagnostic crossover, and identify predictors of outcome. Greater severity in each ARFID profile—sensory sensitivity, fear of aversive consequences, and lack of interest—was hypothesized to predict greater likelihood of illness persistence, controlling for age, sex, body mass index percentile, ARFID treatment status, and baseline diagnosis. Method: Participants (N = 100; age range, 9-23 years; 49% female; 91% White) were followed over 2 years. The Pica, ARFID, and Rumination Disorder Interview was used across 3 time points (baseline, year 1, year 2) to measure the severity of each ARFID profile and evaluate illness persistence or remission, and the Eating Disorder Assessment for DSM-5 was used to evaluate diagnostic crossover. Results: Across the 2-year follow-up period, half the participants persisted with their original diagnosis, and 3% of participants experienced a diagnostic shift to anorexia nervosa. Greater severity in the sensory sensitivity and lack of interest profiles was associated with higher likelihood of ARFID persistence at year 1 only; greater severity in the fear of aversive consequences profile was associated with higher likelihood of ARFID remission at year 2 only. Conclusion: Findings underscore the distinctiveness of ARFID from other eating disorders and emphasize its persistence over 2 years. Results also highlight the predictive validity and prognostic value of the ARFID profiles (ie, sensory sensitivity, fear of aversive consequences, lack of interest). Plain language summary: In this longitudinal study, the authors examined the course and outcomes of avoidant/restrictive food intake disorder (ARFID) in a sample of 100 youth aged 9 to 23 years over the course of 2 years. Across the 2-year follow-up period, half the sample persisted with their original diagnosis, and 3% of participants developed anorexia nervosa. Results indicate that profiles of greater sensory sensitivity to food and lack of interest in food/eating were associated with higher likelihood of ARFID persistence at year 1 only, whereas greater severity in the fear of aversive consequences of eating was associated with higher likelihood of ARFID remission at year 2 only. These findings highlight the persistence of ARFID and suggest that outcomes may vary depending on an individual's ARFID presentation.
KW - ARFID
KW - avoidant/restrictive food intake disorder
KW - feeding and eating disorders
KW - longitudinal course
KW - longitudinal study
UR - http://www.scopus.com/inward/record.url?scp=85196805268&partnerID=8YFLogxK
U2 - 10.1016/j.jaac.2024.04.010
DO - 10.1016/j.jaac.2024.04.010
M3 - Article
C2 - 38718975
AN - SCOPUS:85196805268
SN - 0890-8567
VL - 64
SP - 262
EP - 275
JO - Journal of the American Academy of Child and Adolescent Psychiatry
JF - Journal of the American Academy of Child and Adolescent Psychiatry
IS - 2
ER -