Proresorptive actions of FSH and bone loss

Mone Zaidi, Harry C. Blair, Jameel Iqbal, Ling Ling Zhu, T. Rajendra Kumar, Alberta Zallone, Li Sun

Research output: Chapter in Book/Report/Conference proceedingConference contributionpeer-review

32 Scopus citations

Abstract

We review studies that propose follicle-stimulating hormone (FSH) as a physiologic stimulator of osteoclastic bone resorption. We hypothesize that, in addition to low estrogen, a rising FSH contributes to the increased bone resorption and bone loss in hypergonadism. This is of particular relevance to the perimenopausal transition, wherein profound bone loss is accompanied by trabecular perforations in the face of high FSH and normal estrogen levels. Potential therapeutic implications include the development of antagonists to both circulating FSH and its osteoclastic receptor.

Original languageEnglish
Title of host publicationSkeletal Biology and Medicine, Part A
Subtitle of host publicationAspects of Bone Morphogenesis and Remodeling
PublisherBlackwell Publishing Inc.
Pages376-382
Number of pages7
ISBN (Print)9781573316842
DOIs
StatePublished - Nov 2007

Publication series

NameAnnals of the New York Academy of Sciences
Volume1116
ISSN (Print)0077-8923
ISSN (Electronic)1749-6632

Keywords

  • Hypogonadism
  • Osteoclast
  • Osteoporosis

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