@article{61db12af882c41c7aae49ad71deaa096,
title = "Propranolol and angina pectoris",
abstract = "Propranolol may offer an approach to the treatment of anginal pain which is refractory to conventional modes of therapy. Its efficacy may result from (1) lowering both left ventricular mechanical and metabolic requirements, (2) interference with sensory perception of anginal pain, or (3) blockade of adrenergic coronary vasoconstrictor activity which may precipitate angina in some subjects. Neither clinical nor resting physiologic data seem to be of value in predicting the response of a given patient to the drug.",
author = "Steven Wolfson and Heinle, {Robert A.} and Herman, {Michael V.} and Kemp, {Harvey G.} and Sullivan, {Jay M.} and Richard Gorlin",
note = "Funding Information: Observations were made in the control state and 20 minutes after intravenous infusion of 5 mg. of propranolol; this dose represents the average amount used in the treatment of cardiac arrhythmias. Furthermore, blockade of the beta adrenergic efiect of isoproterenol and I-epinephrine has been achieved at this level in our laboratory. While more ..complete” receptor blockade may have been obtained with larger doses of propranolol, it may also have resulted in nonspecific myocardial depressi0n.Y I{\textquoteright} Left ventricular, brachial artery and coronary sinus pressures. and cardiac output by indocyanine green dilution method were measured. In addition. by sampling blood through appropriately placed catheters, arterial and coronav venous oxygen and lactate concentrations were mcasured.lY The normal heart invariably extracts lactate. Diminished extraction (<toy,), or actual production of lactate by the heart, is accepted by our laboratory as indicating glycolysis (and, by inference, ischemia) in coronary artery disease.{\textquoteleft}:{\textquoteright} Coronary flow was measured by injection of krypton85 (dissolved in saline) into the left ventricle and then determining the level of radioactivity in serially collected samples of coronary sinus blood.” Flow per 100 gm. of left ventricle was then derived from the rate of washout of the tracer. and oxygen consumption per 100 gm. per minute calculated accordingly.15 End-diastolic and end-systolic left ventricular volumes were measured by the thermo- * From the Cardiovascular Research Laboratory, Department Bent Brigham Hospital, Boston, Mass. This study was supported Public Health Service. t Postdoctoral Fellow, U. S. Public Health Service. $ Invrstigator, Howard Hughes Medical Institute.",
year = "1966",
month = oct,
doi = "10.1016/0002-9149(66)90052-X",
language = "English",
volume = "18",
pages = "345--353",
journal = "American Journal of Cardiology",
issn = "0002-9149",
publisher = "Elsevier Inc.",
number = "3",
}