Proportion of biopsy specimens containing a tumor when compared to all biopsy specimens by transbronchial biopsy

Shinnosuke Takemoto; Mutsumi Ozasa; Remi Mizuta; Ryuta Tagawa; Sawana Ono; Noritaka Honda; Takayuki Suyama; Yasuhiro Umeyama; Yosuke Dotsu; Hiroshi Gyotoku; Hiroyuki Yamaguchi; Kazuko Yamamoto; Noriho Sakamoto; Yasushi Obase; Minoru Fukuda; Hiroshi Mukae

doi:10.2217/lmt-2022-0001

Proportion of biopsy specimens containing a tumor when compared to all biopsy specimens by transbronchial biopsy

Shinnosuke Takemoto, Mutsumi Ozasa, Remi Mizuta, Ryuta Tagawa, Sawana Ono, Noritaka Honda, Takayuki Suyama, Yasuhiro Umeyama, Yosuke Dotsu, Hiroshi Gyotoku, Hiroyuki Yamaguchi, Kazuko Yamamoto, Noriho Sakamoto, Yasushi Obase, Minoru Fukuda, Hiroshi Mukae

Research output: Contribution to journal › Article › peer-review

Abstract

Background: The lung cancer biopsy specimens obtained by endobronchial ultrasound-guide sheath (EBUS-GS) trans lung biopsy occasionally do not contain cancer cells. It is a problem that there is a possibility that they may not contain cancer cells. Aim of the study: To investigate the proportion of biopsy specimens containing cancer cells in total biopsy specimens. Materials & methods: Patients with lung cancer diagnosed by EBUS-GS were selected. The primary end point was the proportion of specimens containing tumors in the total specimens obtained by EBUS-GS. Results: Twenty-six patients were investigated. The percentage of specimens containing cancer cells in the total specimens was 79.0%. Conclusion: The proportion of biopsy specimens containing cancer cell to all biopsy specimens by EBUS-GS was high, but not 100%. Plain language summary The lung cancer biopsy specimens obtained by trans lung biopsy occasionally do not contain cancer cells. It is a problem that there is a possibility that they may not contain cancer cells. If the biopsy specimens contained no malignant cells, there was a possibility that accurate genetic test would not be performed and as a result, the correct molecular targeted drug would not be used. It is important to investigate the proportion of biopsy specimens containing cancer cells in total biopsy specimens. In this study, we showed the percentage of specimens containing cancer cells in the total specimens was 79.0%. This result should be considered to perform genetic test from biopsy specimens.

Original language	English
Article number	0001
Journal	Lung Cancer Management
Volume	11
Issue number	4
DOIs	https://doi.org/10.2217/lmt-2022-0001
State	Published - 1 Feb 2023
Externally published	Yes

Keywords

EBUS-GS
biopsy
lung cancer
proportion

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10.2217/lmt-2022-0001

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Takemoto, S., Ozasa, M., Mizuta, R., Tagawa, R., Ono, S., Honda, N., Suyama, T., Umeyama, Y., Dotsu, Y., Gyotoku, H., Yamaguchi, H., Yamamoto, K., Sakamoto, N., Obase, Y., Fukuda, M., & Mukae, H. (2023). Proportion of biopsy specimens containing a tumor when compared to all biopsy specimens by transbronchial biopsy. Lung Cancer Management, 11(4), Article 0001. https://doi.org/10.2217/lmt-2022-0001

@article{dc898ffbd1614afca67da9854bf7a982,

title = "Proportion of biopsy specimens containing a tumor when compared to all biopsy specimens by transbronchial biopsy",

abstract = "Background: The lung cancer biopsy specimens obtained by endobronchial ultrasound-guide sheath (EBUS-GS) trans lung biopsy occasionally do not contain cancer cells. It is a problem that there is a possibility that they may not contain cancer cells. Aim of the study: To investigate the proportion of biopsy specimens containing cancer cells in total biopsy specimens. Materials & methods: Patients with lung cancer diagnosed by EBUS-GS were selected. The primary end point was the proportion of specimens containing tumors in the total specimens obtained by EBUS-GS. Results: Twenty-six patients were investigated. The percentage of specimens containing cancer cells in the total specimens was 79.0%. Conclusion: The proportion of biopsy specimens containing cancer cell to all biopsy specimens by EBUS-GS was high, but not 100%. Plain language summary The lung cancer biopsy specimens obtained by trans lung biopsy occasionally do not contain cancer cells. It is a problem that there is a possibility that they may not contain cancer cells. If the biopsy specimens contained no malignant cells, there was a possibility that accurate genetic test would not be performed and as a result, the correct molecular targeted drug would not be used. It is important to investigate the proportion of biopsy specimens containing cancer cells in total biopsy specimens. In this study, we showed the percentage of specimens containing cancer cells in the total specimens was 79.0%. This result should be considered to perform genetic test from biopsy specimens.",

keywords = "EBUS-GS, biopsy, lung cancer, proportion",

author = "Shinnosuke Takemoto and Mutsumi Ozasa and Remi Mizuta and Ryuta Tagawa and Sawana Ono and Noritaka Honda and Takayuki Suyama and Yasuhiro Umeyama and Yosuke Dotsu and Hiroshi Gyotoku and Hiroyuki Yamaguchi and Kazuko Yamamoto and Noriho Sakamoto and Yasushi Obase and Minoru Fukuda and Hiroshi Mukae",

note = "Publisher Copyright: {\textcopyright} 2023 Shinnosuke Takemoto.",

year = "2023",

month = feb,

day = "1",

doi = "10.2217/lmt-2022-0001",

language = "English",

volume = "11",

journal = "Lung Cancer Management",

issn = "1758-1966",

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Takemoto, S, Ozasa, M, Mizuta, R, Tagawa, R, Ono, S, Honda, N, Suyama, T, Umeyama, Y, Dotsu, Y, Gyotoku, H, Yamaguchi, H, Yamamoto, K, Sakamoto, N, Obase, Y, Fukuda, M & Mukae, H 2023, 'Proportion of biopsy specimens containing a tumor when compared to all biopsy specimens by transbronchial biopsy', Lung Cancer Management, vol. 11, no. 4, 0001. https://doi.org/10.2217/lmt-2022-0001

TY - JOUR

T1 - Proportion of biopsy specimens containing a tumor when compared to all biopsy specimens by transbronchial biopsy

AU - Takemoto, Shinnosuke

AU - Ozasa, Mutsumi

AU - Mizuta, Remi

AU - Tagawa, Ryuta

AU - Ono, Sawana

AU - Honda, Noritaka

AU - Suyama, Takayuki

AU - Umeyama, Yasuhiro

AU - Dotsu, Yosuke

AU - Gyotoku, Hiroshi

AU - Yamaguchi, Hiroyuki

AU - Yamamoto, Kazuko

AU - Sakamoto, Noriho

AU - Obase, Yasushi

AU - Fukuda, Minoru

AU - Mukae, Hiroshi

PY - 2023/2/1

Y1 - 2023/2/1

N2 - Background: The lung cancer biopsy specimens obtained by endobronchial ultrasound-guide sheath (EBUS-GS) trans lung biopsy occasionally do not contain cancer cells. It is a problem that there is a possibility that they may not contain cancer cells. Aim of the study: To investigate the proportion of biopsy specimens containing cancer cells in total biopsy specimens. Materials & methods: Patients with lung cancer diagnosed by EBUS-GS were selected. The primary end point was the proportion of specimens containing tumors in the total specimens obtained by EBUS-GS. Results: Twenty-six patients were investigated. The percentage of specimens containing cancer cells in the total specimens was 79.0%. Conclusion: The proportion of biopsy specimens containing cancer cell to all biopsy specimens by EBUS-GS was high, but not 100%. Plain language summary The lung cancer biopsy specimens obtained by trans lung biopsy occasionally do not contain cancer cells. It is a problem that there is a possibility that they may not contain cancer cells. If the biopsy specimens contained no malignant cells, there was a possibility that accurate genetic test would not be performed and as a result, the correct molecular targeted drug would not be used. It is important to investigate the proportion of biopsy specimens containing cancer cells in total biopsy specimens. In this study, we showed the percentage of specimens containing cancer cells in the total specimens was 79.0%. This result should be considered to perform genetic test from biopsy specimens.

AB - Background: The lung cancer biopsy specimens obtained by endobronchial ultrasound-guide sheath (EBUS-GS) trans lung biopsy occasionally do not contain cancer cells. It is a problem that there is a possibility that they may not contain cancer cells. Aim of the study: To investigate the proportion of biopsy specimens containing cancer cells in total biopsy specimens. Materials & methods: Patients with lung cancer diagnosed by EBUS-GS were selected. The primary end point was the proportion of specimens containing tumors in the total specimens obtained by EBUS-GS. Results: Twenty-six patients were investigated. The percentage of specimens containing cancer cells in the total specimens was 79.0%. Conclusion: The proportion of biopsy specimens containing cancer cell to all biopsy specimens by EBUS-GS was high, but not 100%. Plain language summary The lung cancer biopsy specimens obtained by trans lung biopsy occasionally do not contain cancer cells. It is a problem that there is a possibility that they may not contain cancer cells. If the biopsy specimens contained no malignant cells, there was a possibility that accurate genetic test would not be performed and as a result, the correct molecular targeted drug would not be used. It is important to investigate the proportion of biopsy specimens containing cancer cells in total biopsy specimens. In this study, we showed the percentage of specimens containing cancer cells in the total specimens was 79.0%. This result should be considered to perform genetic test from biopsy specimens.

KW - EBUS-GS

KW - biopsy

KW - lung cancer

KW - proportion

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U2 - 10.2217/lmt-2022-0001

DO - 10.2217/lmt-2022-0001

M3 - Article

AN - SCOPUS:85163296598

SN - 1758-1966

VL - 11

JO - Lung Cancer Management

JF - Lung Cancer Management

IS - 4

M1 - 0001

ER -

Proportion of biopsy specimens containing a tumor when compared to all biopsy specimens by transbronchial biopsy

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Keywords

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