TY - JOUR
T1 - Propofol combined with lorazepam for severe poly substance misuse and withdrawal states in intensive care unit
T2 - A case series and review
AU - Subramaniam, Kathirvels
AU - Gowda, R. M.
AU - Jani, K.
AU - Zewedie, W.
AU - Ute, R.
PY - 2004/9
Y1 - 2004/9
N2 - A safe, rapid, and effective way to detoxify patients from substance misuse is important in facilitating further treatment of their psychiatric or substance use disorder. This paper discusses the treatment of acute withdrawal from polysubstance misuse in three patients in the intensive care unit setting using combined sedation with a benzodiazepine, lorazepam, and a general anaesthetic, propofol. Lorazepam alone was not effective in massive doses in these cases. The advantages and mechanism of action of using multiple agents to control refractory symptoms is discussed.
AB - A safe, rapid, and effective way to detoxify patients from substance misuse is important in facilitating further treatment of their psychiatric or substance use disorder. This paper discusses the treatment of acute withdrawal from polysubstance misuse in three patients in the intensive care unit setting using combined sedation with a benzodiazepine, lorazepam, and a general anaesthetic, propofol. Lorazepam alone was not effective in massive doses in these cases. The advantages and mechanism of action of using multiple agents to control refractory symptoms is discussed.
UR - http://www.scopus.com/inward/record.url?scp=4544237559&partnerID=8YFLogxK
U2 - 10.1136/emj.2003.007526
DO - 10.1136/emj.2003.007526
M3 - Article
C2 - 15333553
AN - SCOPUS:4544237559
SN - 1472-0205
VL - 21
SP - 632
EP - 634
JO - Emergency Medicine Journal
JF - Emergency Medicine Journal
IS - 5
ER -