Promyelocytic leukemia zinc finger-retinoic acid receptor - (PLZF-RAR-), an oncogenic transcriptional repressor of cyclin-dependent kinase inhibitor 1A (p21WAF/CDKN1A) and tumor protein p53 (TP53) genes Won-Il Choi

Jae Hyeon Yoon; Min Young Kim; Dong In Koh; Jonathan D. Licht; Kunhong Kim; Man Wook Hur

doi:10.1074/jbc.M113.538777

Promyelocytic leukemia zinc finger-retinoic acid receptor - (PLZF-RAR-), an oncogenic transcriptional repressor of cyclin-dependent kinase inhibitor 1A (p21WAF/CDKN1A) and tumor protein p53 (TP53) genes Won-Il Choi

Jae Hyeon Yoon
, Min Young Kim
, Dong In Koh
, Jonathan D. Licht
, Kunhong Kim
, Man Wook Hur

Research output: Contribution to journal › Article › peer-review

20 Scopus citations

Abstract

Background: Promyelocytic leukemia zinc finger-retinoic acid receptor - (PLZF-RAR-) is a transcriptional repressor generated by a chromosomal translocation between the PLZF and RAR- genes in acute promyelocyteic leukemia patients. Results: The transcriptional regulation ofCDKN1Aby PLZF-RAR- involves the competitive binding of p53,RAR-, and Sp1, the modification of histones, and DNA methylation at the promoter. Conclusion: PLZF-RAR- increases cell proliferation by repressing p21 expression. Significance: Oncoprotein PLZF-RAR- represses transcription of the CDKN1A.

Original language	English
Pages (from-to)	18641-18656
Number of pages	16
Journal	Journal of Biological Chemistry
Volume	289
Issue number	27
DOIs	https://doi.org/10.1074/jbc.M113.538777
State	Published - 4 Jul 2014
Externally published	Yes

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Yoon, J. H., Kim, M. Y., Koh, D. I., Licht, J. D., Kim, K., & Hur, M. W. (2014). Promyelocytic leukemia zinc finger-retinoic acid receptor - (PLZF-RAR-), an oncogenic transcriptional repressor of cyclin-dependent kinase inhibitor 1A (p21WAF/CDKN1A) and tumor protein p53 (TP53) genes Won-Il Choi. Journal of Biological Chemistry, 289(27), 18641-18656. https://doi.org/10.1074/jbc.M113.538777

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title = "Promyelocytic leukemia zinc finger-retinoic acid receptor - (PLZF-RAR-), an oncogenic transcriptional repressor of cyclin-dependent kinase inhibitor 1A (p21WAF/CDKN1A) and tumor protein p53 (TP53) genes Won-Il Choi",

abstract = "Background: Promyelocytic leukemia zinc finger-retinoic acid receptor - (PLZF-RAR-) is a transcriptional repressor generated by a chromosomal translocation between the PLZF and RAR- genes in acute promyelocyteic leukemia patients. Results: The transcriptional regulation ofCDKN1Aby PLZF-RAR- involves the competitive binding of p53,RAR-, and Sp1, the modification of histones, and DNA methylation at the promoter. Conclusion: PLZF-RAR- increases cell proliferation by repressing p21 expression. Significance: Oncoprotein PLZF-RAR- represses transcription of the CDKN1A.",

author = "Yoon, \{Jae Hyeon\} and Kim, \{Min Young\} and Koh, \{Dong In\} and Licht, \{Jonathan D.\} and Kunhong Kim and Hur, \{Man Wook\}",

year = "2014",

month = jul,

day = "4",

doi = "10.1074/jbc.M113.538777",

language = "English",

volume = "289",

pages = "18641--18656",

journal = "Journal of Biological Chemistry",

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Yoon, JH, Kim, MY, Koh, DI, Licht, JD, Kim, K & Hur, MW 2014, 'Promyelocytic leukemia zinc finger-retinoic acid receptor - (PLZF-RAR-), an oncogenic transcriptional repressor of cyclin-dependent kinase inhibitor 1A (p21WAF/CDKN1A) and tumor protein p53 (TP53) genes Won-Il Choi', Journal of Biological Chemistry, vol. 289, no. 27, pp. 18641-18656. https://doi.org/10.1074/jbc.M113.538777

Promyelocytic leukemia zinc finger-retinoic acid receptor - (PLZF-RAR-), an oncogenic transcriptional repressor of cyclin-dependent kinase inhibitor 1A (p21WAF/CDKN1A) and tumor protein p53 (TP53) genes Won-Il Choi. / Yoon, Jae Hyeon; Kim, Min Young; Koh, Dong In et al.
In: Journal of Biological Chemistry, Vol. 289, No. 27, 04.07.2014, p. 18641-18656.

Research output: Contribution to journal › Article › peer-review

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T1 - Promyelocytic leukemia zinc finger-retinoic acid receptor - (PLZF-RAR-), an oncogenic transcriptional repressor of cyclin-dependent kinase inhibitor 1A (p21WAF/CDKN1A) and tumor protein p53 (TP53) genes Won-Il Choi

AU - Yoon, Jae Hyeon

AU - Kim, Min Young

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AU - Licht, Jonathan D.

AU - Kim, Kunhong

AU - Hur, Man Wook

PY - 2014/7/4

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N2 - Background: Promyelocytic leukemia zinc finger-retinoic acid receptor - (PLZF-RAR-) is a transcriptional repressor generated by a chromosomal translocation between the PLZF and RAR- genes in acute promyelocyteic leukemia patients. Results: The transcriptional regulation ofCDKN1Aby PLZF-RAR- involves the competitive binding of p53,RAR-, and Sp1, the modification of histones, and DNA methylation at the promoter. Conclusion: PLZF-RAR- increases cell proliferation by repressing p21 expression. Significance: Oncoprotein PLZF-RAR- represses transcription of the CDKN1A.

AB - Background: Promyelocytic leukemia zinc finger-retinoic acid receptor - (PLZF-RAR-) is a transcriptional repressor generated by a chromosomal translocation between the PLZF and RAR- genes in acute promyelocyteic leukemia patients. Results: The transcriptional regulation ofCDKN1Aby PLZF-RAR- involves the competitive binding of p53,RAR-, and Sp1, the modification of histones, and DNA methylation at the promoter. Conclusion: PLZF-RAR- increases cell proliferation by repressing p21 expression. Significance: Oncoprotein PLZF-RAR- represses transcription of the CDKN1A.

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