Promiscuous Activation of Transient Receptor Potential Vanilloid 1 (TRPV1) channels by negatively charged intracellular lipids: The key role of endogenous phosphoinositides in maintaining channel activity

Viktor Lukacs, Jan Michael Rives, Xiaohui Sun, Eleonora Zakharian, Tibor Rohacs

Research output: Contribution to journalArticlepeer-review

52 Scopus citations

Abstract

Background: Regulation of TRPV1 by phosphoinositides is controversial. Results: ATP reactivates TRPV1 after run-down in excised inside-out patches by generating phosphoinositides; many other negatively charged lipids may also support TRPV1 activity. Conclusion: Despite its promiscuous activation, phosphoinositides are the key endogenous cofactors for TRPV1 activity. Significance: Our data may reconcile discordant data obtained in different experimental settings.

Original languageEnglish
Pages (from-to)35003-35013
Number of pages11
JournalJournal of Biological Chemistry
Volume288
Issue number49
DOIs
StatePublished - 6 Dec 2013
Externally publishedYes

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