Prominent mental (chin) crease: A new sign of pseudoxanthoma elasticum

Mark Lebwohl; Eve Lebwohl; Lionel Bercovitch

doi:10.1067/mjd.2003.195

Prominent mental (chin) crease: A new sign of pseudoxanthoma elasticum

Mark Lebwohl
, Eve Lebwohl
, Lionel Bercovitch

Research output: Contribution to journal › Article › peer-review

32 Scopus citations

Abstract

Pseudoxanthoma elasticum (PXE) is an inherited disease with many systemic complications. Its diagnosis can be easily overlooked. The purpose of this study was to assess a new clinical sign of PXE. A total of 47 consecutive patients with PXE were examined for mental creases and compared with 47 age-matched control patients. Photographs were evaluated by a blinded investigator. Mental creases were present in 43 of 47 patients with PXE, affected the majority of individuals in every age group, and were significantly more common than in control patients (P < .0001). Under the age of 30 years, two thirds of patients with PXE had mental creases whereas mental creases were not present in any age-matched control patients. Mental creases commonly occur in patients with PXE. In young patients they are a sensitive and highly specific physical finding of this disorder. The presence of exaggerated mental creases is, thus, a useful physical marker for PXE.

Original language	English
Pages (from-to)	620-622
Number of pages	3
Journal	Journal of the American Academy of Dermatology
Volume	48
Issue number	4
DOIs	https://doi.org/10.1067/mjd.2003.195
State	Published - 1 Apr 2003

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title = "Prominent mental (chin) crease: A new sign of pseudoxanthoma elasticum",

abstract = "Pseudoxanthoma elasticum (PXE) is an inherited disease with many systemic complications. Its diagnosis can be easily overlooked. The purpose of this study was to assess a new clinical sign of PXE. A total of 47 consecutive patients with PXE were examined for mental creases and compared with 47 age-matched control patients. Photographs were evaluated by a blinded investigator. Mental creases were present in 43 of 47 patients with PXE, affected the majority of individuals in every age group, and were significantly more common than in control patients (P < .0001). Under the age of 30 years, two thirds of patients with PXE had mental creases whereas mental creases were not present in any age-matched control patients. Mental creases commonly occur in patients with PXE. In young patients they are a sensitive and highly specific physical finding of this disorder. The presence of exaggerated mental creases is, thus, a useful physical marker for PXE.",

author = "Mark Lebwohl and Eve Lebwohl and Lionel Bercovitch",

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AU - Lebwohl, Mark

AU - Lebwohl, Eve

AU - Bercovitch, Lionel

N1 - Funding Information: Funding sources: Supported by the Food and Drug Administration Orphan Products Development grant FD-R-002161-01 (to M. L.).

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N2 - Pseudoxanthoma elasticum (PXE) is an inherited disease with many systemic complications. Its diagnosis can be easily overlooked. The purpose of this study was to assess a new clinical sign of PXE. A total of 47 consecutive patients with PXE were examined for mental creases and compared with 47 age-matched control patients. Photographs were evaluated by a blinded investigator. Mental creases were present in 43 of 47 patients with PXE, affected the majority of individuals in every age group, and were significantly more common than in control patients (P < .0001). Under the age of 30 years, two thirds of patients with PXE had mental creases whereas mental creases were not present in any age-matched control patients. Mental creases commonly occur in patients with PXE. In young patients they are a sensitive and highly specific physical finding of this disorder. The presence of exaggerated mental creases is, thus, a useful physical marker for PXE.

AB - Pseudoxanthoma elasticum (PXE) is an inherited disease with many systemic complications. Its diagnosis can be easily overlooked. The purpose of this study was to assess a new clinical sign of PXE. A total of 47 consecutive patients with PXE were examined for mental creases and compared with 47 age-matched control patients. Photographs were evaluated by a blinded investigator. Mental creases were present in 43 of 47 patients with PXE, affected the majority of individuals in every age group, and were significantly more common than in control patients (P < .0001). Under the age of 30 years, two thirds of patients with PXE had mental creases whereas mental creases were not present in any age-matched control patients. Mental creases commonly occur in patients with PXE. In young patients they are a sensitive and highly specific physical finding of this disorder. The presence of exaggerated mental creases is, thus, a useful physical marker for PXE.

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JF - Journal of the American Academy of Dermatology

IS - 4

ER -

Prominent mental (chin) crease: A new sign of pseudoxanthoma elasticum

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