Prolyl endopeptidase

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237 Scopus citations


Prolyl endopeptidase (E.C. an enzyme previously called post proline cleaving enzyme, TRH-deamidase or kininase B, may play a role in neuropeptide metabolism. This enzyme, highly active in brain and other tissues, catabolizes proline-containing peptides such as substance P, neurotensin, luteinizing hormonereleasing hormone, thyrotropin releasing hormone, bradykinin and angiotensin II. The structure of β-neo-endorphin suggests that this opioid peptide is formed by the action of prolyl endopeptidase on a precursor of higher molecular weight. Formation of two biologically active fragments of substance P also requires the action of this enzyme. This review summarizes the current knowledge of the biochemistry of this enzyme, and its potential significance for neuropeptide physiology and pharmacology.

Original languageEnglish
Pages (from-to)2149-2157
Number of pages9
JournalLife Sciences
Issue number22
StatePublished - 28 Nov 1983
Externally publishedYes


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