Proliferation of neural stem cells correlates with Wnt-3 protein in hypoxic-ischemic neonate rats after hyperbaric oxygen therapy

Xiao Li Wang, Yu Jia Yang, Min Xie, Xiao He Yu, Chen Tao Liu, Xia Wang

Research output: Contribution to journalArticlepeer-review

32 Scopus citations

Abstract

Hyperbaric oxygen therapy promoted brain cell proliferation. Wnt-3 is closely associated with the proliferation of neural stem cells. We examined whether hyperbaric oxygen promoted neural stem cells to proliferate and its correlation with Wnt-3 protein in hypoxic-ischemic neonate rats. Hyperbaric oxygen therapy was administered 3 h after hypoxia ischemia daily for 7 days. The proliferating stem cells and Wnt-3 protein were examined dynamically in the subventricular zone. Results showed that stem cells proliferated and peaked 7 days after hyperbaric oxygen therapy. Wnt-3 protein increased to the higher levels 3 days after therapy. Linear regression analysis showed that nestin protein correlated with Wnt-3 protein. We propose that hyperbaric oxygen treatment promote stem cells to proliferate, which is correlated with Wnt-3 protein.

Original languageEnglish
Pages (from-to)1753-1756
Number of pages4
JournalNeuroReport
Volume18
Issue number16
DOIs
StatePublished - Oct 2007
Externally publishedYes

Keywords

  • Hyperbaric oxygen
  • Hypoxic-ischemic brain damage
  • Neural stem cells
  • Wnt-3

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