TY - JOUR
T1 - Projections from the dorsomedial division of the bed nucleus of the stria terminalis to hypothalamic nuclei in the mouse
AU - Barbier, Marie
AU - González, J. Antonio
AU - Houdayer, Christophe
AU - Burdakov, Denis
AU - Risold, Pierre Yves
AU - Croizier, Sophie
N1 - Publisher Copyright:
© 2020 The Authors. The Journal of Comparative Neurology published by Wiley Periodicals LLC.
PY - 2021/4/1
Y1 - 2021/4/1
N2 - As stressful environment is a potent modulator of feeding, we seek in the present work to decipher the neuroanatomical basis for an interplay between stress and feeding behaviors. For this, we combined anterograde and retrograde tracing with immunohistochemical approaches to investigate the patterns of projections between the dorsomedial division of the bed nucleus of the stria terminalis (BNST), well connected to the amygdala, and hypothalamic structures such as the paraventricular (PVH) and dorsomedial (DMH), the arcuate (ARH) nuclei and the lateral hypothalamic areas (LHA) known to control feeding and motivated behaviors. We particularly focused our study on afferences to proopiomelanocortin (POMC), agouti-related peptide (AgRP), melanin-concentrating-hormone (MCH) and orexin (ORX) neurons characteristics of the ARH and the LHA, respectively. We found light to intense innervation of all these hypothalamic nuclei. We particularly showed an innervation of POMC, AgRP, MCH and ORX neurons by the dorsomedial and dorsolateral divisions of the BNST. Therefore, these results lay the foundation for a better understanding of the neuroanatomical basis of the stress-related feeding behaviors.
AB - As stressful environment is a potent modulator of feeding, we seek in the present work to decipher the neuroanatomical basis for an interplay between stress and feeding behaviors. For this, we combined anterograde and retrograde tracing with immunohistochemical approaches to investigate the patterns of projections between the dorsomedial division of the bed nucleus of the stria terminalis (BNST), well connected to the amygdala, and hypothalamic structures such as the paraventricular (PVH) and dorsomedial (DMH), the arcuate (ARH) nuclei and the lateral hypothalamic areas (LHA) known to control feeding and motivated behaviors. We particularly focused our study on afferences to proopiomelanocortin (POMC), agouti-related peptide (AgRP), melanin-concentrating-hormone (MCH) and orexin (ORX) neurons characteristics of the ARH and the LHA, respectively. We found light to intense innervation of all these hypothalamic nuclei. We particularly showed an innervation of POMC, AgRP, MCH and ORX neurons by the dorsomedial and dorsolateral divisions of the BNST. Therefore, these results lay the foundation for a better understanding of the neuroanatomical basis of the stress-related feeding behaviors.
KW - AgRP/NPY
KW - MCH
KW - ORX
KW - POMC
KW - anterograde and retrograde tract tracing
KW - dorsomedial division of the bed nucleus of the stria terminalis
KW - hypothalamic nuclei
UR - http://www.scopus.com/inward/record.url?scp=85088825676&partnerID=8YFLogxK
U2 - 10.1002/cne.24988
DO - 10.1002/cne.24988
M3 - Article
C2 - 32678476
AN - SCOPUS:85088825676
SN - 0021-9967
VL - 529
SP - 929
EP - 956
JO - Journal of Comparative Neurology
JF - Journal of Comparative Neurology
IS - 5
ER -