Progressive transformation of the cytoskeleton associated with normal aging and Alzheimer's disease

James C. Vickers; André Delacourte; John H. Morrison

doi:10.1016/0006-8993(92)91134-Z

Progressive transformation of the cytoskeleton associated with normal aging and Alzheimer's disease

James C. Vickers
, André Delacourte
, John H. Morrison

Icahn School of Medicine at Mount Sinai

Research output: Contribution to journal › Article › peer-review

96 Scopus citations

Abstract

Transitional and end-stage forms of neurofibrillary tangles associated with normal aging and Alzheimer's disease were identified using thioflavine staining combined with tau and neurofilament protein immunofluorescence. Normal aging was marked by transitional pathology in layer II of the entorhinal cortex but no neurofibrillary tangles in prefrontal cortex, in Alheimer's disease cases, layer II entorhinal neurons had progressed to end-stage neurofibrillary tangles and the prefrontal cortex contained a hign representation of transitional forms of the neurofibrillary tangle.

Original language	English
Pages (from-to)	273-278
Number of pages	6
Journal	Brain Research
Volume	594
Issue number	2
DOIs	https://doi.org/10.1016/0006-8993(92)91134-Z
State	Published - 30 Oct 1992

Keywords

Aging
Alzheimer's disease
Dementia
Neurofibrillary tangle
Neurofilament
Tau
Thioflavine

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10.1016/0006-8993(92)91134-Z

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@article{4431f997111f4b06a5ef516f570dd9cb,

title = "Progressive transformation of the cytoskeleton associated with normal aging and Alzheimer's disease",

abstract = "Transitional and end-stage forms of neurofibrillary tangles associated with normal aging and Alzheimer's disease were identified using thioflavine staining combined with tau and neurofilament protein immunofluorescence. Normal aging was marked by transitional pathology in layer II of the entorhinal cortex but no neurofibrillary tangles in prefrontal cortex, in Alheimer's disease cases, layer II entorhinal neurons had progressed to end-stage neurofibrillary tangles and the prefrontal cortex contained a hign representation of transitional forms of the neurofibrillary tangle.",

keywords = "Aging, Alzheimer's disease, Dementia, Neurofibrillary tangle, Neurofilament, Tau, Thioflavine",

author = "Vickers, \{James C.\} and Andr{\'e} Delacourte and Morrison, \{John H.\}",

note = "Funding Information: We would like to thank our colleagues at the Fishberg Research Center for Neurobiology as well as Dr. John Trojanowski aad Dr. Neil Kowall for their valued comments on the manuscript. We also thank William Janssen for technical support and Bob Woolley for photographic assistance, in addition, we would like to acknowledge the Institute of Biogerontology Research Tissue Donation Program (Sun City, Arizona) for the provision of many of the cases in the present study. This work was funded by AG05138 and AG06647 from the National Institute for Aging and AHAF. James Vickers is a recipient of a CJ. Martin Postdoctoral Fellowship from the Australian National Health and Medical Research Council.",

year = "1992",

month = oct,

day = "30",

doi = "10.1016/0006-8993(92)91134-Z",

language = "English",

volume = "594",

pages = "273--278",

journal = "Brain Research",

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TY - JOUR

T1 - Progressive transformation of the cytoskeleton associated with normal aging and Alzheimer's disease

AU - Vickers, James C.

AU - Delacourte, André

AU - Morrison, John H.

N1 - Funding Information: We would like to thank our colleagues at the Fishberg Research Center for Neurobiology as well as Dr. John Trojanowski aad Dr. Neil Kowall for their valued comments on the manuscript. We also thank William Janssen for technical support and Bob Woolley for photographic assistance, in addition, we would like to acknowledge the Institute of Biogerontology Research Tissue Donation Program (Sun City, Arizona) for the provision of many of the cases in the present study. This work was funded by AG05138 and AG06647 from the National Institute for Aging and AHAF. James Vickers is a recipient of a CJ. Martin Postdoctoral Fellowship from the Australian National Health and Medical Research Council.

PY - 1992/10/30

Y1 - 1992/10/30

N2 - Transitional and end-stage forms of neurofibrillary tangles associated with normal aging and Alzheimer's disease were identified using thioflavine staining combined with tau and neurofilament protein immunofluorescence. Normal aging was marked by transitional pathology in layer II of the entorhinal cortex but no neurofibrillary tangles in prefrontal cortex, in Alheimer's disease cases, layer II entorhinal neurons had progressed to end-stage neurofibrillary tangles and the prefrontal cortex contained a hign representation of transitional forms of the neurofibrillary tangle.

AB - Transitional and end-stage forms of neurofibrillary tangles associated with normal aging and Alzheimer's disease were identified using thioflavine staining combined with tau and neurofilament protein immunofluorescence. Normal aging was marked by transitional pathology in layer II of the entorhinal cortex but no neurofibrillary tangles in prefrontal cortex, in Alheimer's disease cases, layer II entorhinal neurons had progressed to end-stage neurofibrillary tangles and the prefrontal cortex contained a hign representation of transitional forms of the neurofibrillary tangle.

KW - Aging

KW - Alzheimer's disease

KW - Dementia

KW - Neurofibrillary tangle

KW - Neurofilament

KW - Tau

KW - Thioflavine

UR - https://www.scopus.com/pages/publications/0026564018

U2 - 10.1016/0006-8993(92)91134-Z

DO - 10.1016/0006-8993(92)91134-Z

M3 - Article

C2 - 1450952

AN - SCOPUS:0026564018

SN - 0006-8993

VL - 594

SP - 273

EP - 278

JO - Brain Research

JF - Brain Research

IS - 2

ER -

Progressive transformation of the cytoskeleton associated with normal aging and Alzheimer's disease

Abstract

Keywords

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