@article{4431f997111f4b06a5ef516f570dd9cb,
title = "Progressive transformation of the cytoskeleton associated with normal aging and Alzheimer's disease",
abstract = "Transitional and end-stage forms of neurofibrillary tangles associated with normal aging and Alzheimer's disease were identified using thioflavine staining combined with tau and neurofilament protein immunofluorescence. Normal aging was marked by transitional pathology in layer II of the entorhinal cortex but no neurofibrillary tangles in prefrontal cortex, in Alheimer's disease cases, layer II entorhinal neurons had progressed to end-stage neurofibrillary tangles and the prefrontal cortex contained a hign representation of transitional forms of the neurofibrillary tangle.",
keywords = "Aging, Alzheimer's disease, Dementia, Neurofibrillary tangle, Neurofilament, Tau, Thioflavine",
author = "Vickers, {James C.} and Andr{\'e} Delacourte and Morrison, {John H.}",
note = "Funding Information: We would like to thank our colleagues at the Fishberg Research Center for Neurobiology as well as Dr. John Trojanowski aad Dr. Neil Kowall for their valued comments on the manuscript. We also thank William Janssen for technical support and Bob Woolley for photographic assistance, in addition, we would like to acknowledge the Institute of Biogerontology Research Tissue Donation Program (Sun City, Arizona) for the provision of many of the cases in the present study. This work was funded by AG05138 and AG06647 from the National Institute for Aging and AHAF. James Vickers is a recipient of a CJ. Martin Postdoctoral Fellowship from the Australian National Health and Medical Research Council.",
year = "1992",
month = oct,
day = "30",
doi = "10.1016/0006-8993(92)91134-Z",
language = "English",
volume = "594",
pages = "273--278",
journal = "Brain Research",
issn = "0006-8993",
publisher = "Elsevier",
number = "2",
}