Progressive irradiation dementia and psychosis

Hillel Grossman; Eric D. Caine; Leena Ketonen

Progressive irradiation dementia and psychosis

Hillel Grossman
, Eric D. Caine
, Leena Ketonen

Research output: Contribution to journal › Article › peer-review

Abstract

A 50-year-old woman, who survived 12 years following cranial irradiation for a frontal tumor, developed a delayed-onset, progressive neuropsychi-atric disorder culminating in florid psychosis. Her symptoms and deficits fit the clinical pattern of a progressive subcortical disease and correlated with neuro-imaging evidence of continuing white matter degeneration. We compare this irradiation-induced dementia to other toxic and degenerative dementias, and consider the role of cerebral white matter in the genesis of psychotic symptoms.

Original language	English
Pages (from-to)	122-124
Number of pages	3
Journal	Neuropsychiatry, Neuropsychology and Behavioral Neurology
Volume	7
Issue number	2
State	Published - Apr 1994
Externally published	Yes

Keywords

Dementia
Neuropsychological testing
Radiotherapy

Cite this

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title = "Progressive irradiation dementia and psychosis",

abstract = "A 50-year-old woman, who survived 12 years following cranial irradiation for a frontal tumor, developed a delayed-onset, progressive neuropsychi-atric disorder culminating in florid psychosis. Her symptoms and deficits fit the clinical pattern of a progressive subcortical disease and correlated with neuro-imaging evidence of continuing white matter degeneration. We compare this irradiation-induced dementia to other toxic and degenerative dementias, and consider the role of cerebral white matter in the genesis of psychotic symptoms.",

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author = "Hillel Grossman and Caine, \{Eric D.\} and Leena Ketonen",

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AU - Grossman, Hillel

AU - Caine, Eric D.

AU - Ketonen, Leena

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N2 - A 50-year-old woman, who survived 12 years following cranial irradiation for a frontal tumor, developed a delayed-onset, progressive neuropsychi-atric disorder culminating in florid psychosis. Her symptoms and deficits fit the clinical pattern of a progressive subcortical disease and correlated with neuro-imaging evidence of continuing white matter degeneration. We compare this irradiation-induced dementia to other toxic and degenerative dementias, and consider the role of cerebral white matter in the genesis of psychotic symptoms.

AB - A 50-year-old woman, who survived 12 years following cranial irradiation for a frontal tumor, developed a delayed-onset, progressive neuropsychi-atric disorder culminating in florid psychosis. Her symptoms and deficits fit the clinical pattern of a progressive subcortical disease and correlated with neuro-imaging evidence of continuing white matter degeneration. We compare this irradiation-induced dementia to other toxic and degenerative dementias, and consider the role of cerebral white matter in the genesis of psychotic symptoms.

KW - Dementia

KW - Neuropsychological testing

KW - Radiotherapy

UR - https://www.scopus.com/pages/publications/84939074209

M3 - Article

AN - SCOPUS:84939074209

SN - 0894-878X

VL - 7

SP - 122

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JO - Neuropsychiatry, Neuropsychology and Behavioral Neurology

JF - Neuropsychiatry, Neuropsychology and Behavioral Neurology

IS - 2

ER -

Progressive irradiation dementia and psychosis

Abstract

Keywords

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