Progression of local glaucomatous damage near fixation as seen with adaptive optics imaging

Donald C. Hood, Dongwon Lee, Ravivarn Jarukasetphon, Jason Nunez, Maria A. Mavrommatis, Richard B. Rosen, Robert Ritch, Alfredo Dubra, Toco Y.P. Chui

Research output: Contribution to journalArticlepeer-review

10 Scopus citations


Purpose: Deep glaucomatous defects near fixation were followed over time with an adaptive optics-scanning light ophthalmoscope (AO-SLO) to better understand the progression of these defects and to explore the use of AO-SLO in detecting them. Methods: Six eyes of 5 patients were imaged with an AO-SLO from 2 to 4 times for a range of 14.6 to 33.6 months. All eyes had open-angle glaucoma with deep defects in the superior visual field (VF) near fixation as defined by 10-2 VFs with 5 or more points less than 15 – dB; two of the eyes had deep defects in the inferior VF as well. AO-SLO images were obtained around the temporal edge of the disc. Results: In 4 of the 6 eyes, the edge of the inferior-temporal disc region of the retinal nerve fiber (RNF) defect seen on AO-SLO moved closer to fixation within 10.6 to 14.7 months. In 4 eyes, RNF bundles in the affected region appeared to lose contrast and/ or disappear. Conclusions: Progressive changes in RNF bundles associated with deep defects on 10-2 VFs can be seen within about 1 year with AO-SLO imaging. These changes are well below the spatial resolution of the 10-2 VF. On the other hand, subtle thinning of regions with RNF bundles is not easy to see with current AO-SLO technology, and may be better followed with OCT. Translational Relevance: AO-SLO imaging may be useful in clinical trials designed to see very small changes in deep defects.

Original languageEnglish
Article number6
JournalTranslational Vision Science and Technology
Issue number4
StatePublished - 1 Jul 2017
Externally publishedYes


  • Adaptive optics
  • Glaucoma
  • Retinal nerve fiber


Dive into the research topics of 'Progression of local glaucomatous damage near fixation as seen with adaptive optics imaging'. Together they form a unique fingerprint.

Cite this