Progression of kidney disease as a maladaptive response to injury

Xuezhu Li; Feng Ding; Kyung Lee; John Cijiang He

doi:10.1016/B978-0-12-823318-4.00033-0

Progression of kidney disease as a maladaptive response to injury

Xuezhu Li, Feng Ding, Kyung Lee, John Cijiang He

Research output: Chapter in Book/Report/Conference proceeding › Chapter › peer-review

Abstract

The kidney is vulnerable to acute kidney injury (AKI), the repair can make injury back to normal when minimal to mild, while also can be maladaptive when the damage is severe or persisted, and lead to chronic kidney disease (CKD). An organelle is a substructure that is directly related to various essential biological reactions within the cell, e.g., mitochondria, endoplasmic reticulum (ER), and lysosomes. Organelles stress and their crosstalk play an important role in the maladaptive response in various kidney injury. An elucidation of these mechanisms may help us to identify potential new therapeutic targets for both AKI and CKD. The role of organelles in mediating maladaptive response in kidney injury are summarized in this chapter.

Original language	English
Title of host publication	Regenerative Nephrology
Publisher	Elsevier
Pages	213-220
Number of pages	8
ISBN (Electronic)	9780128233184
DOIs	https://doi.org/10.1016/B978-0-12-823318-4.00033-0
State	Published - 1 Jan 2021

Keywords

Endoplasmic reticulum
Kidney injury
Maladaptive response
Mitochondria
Organelle

Access to Document

10.1016/B978-0-12-823318-4.00033-0

Cite this

@inbook{510af535013d46f882f19a2fb5709117,

title = "Progression of kidney disease as a maladaptive response to injury",

abstract = "The kidney is vulnerable to acute kidney injury (AKI), the repair can make injury back to normal when minimal to mild, while also can be maladaptive when the damage is severe or persisted, and lead to chronic kidney disease (CKD). An organelle is a substructure that is directly related to various essential biological reactions within the cell, e.g., mitochondria, endoplasmic reticulum (ER), and lysosomes. Organelles stress and their crosstalk play an important role in the maladaptive response in various kidney injury. An elucidation of these mechanisms may help us to identify potential new therapeutic targets for both AKI and CKD. The role of organelles in mediating maladaptive response in kidney injury are summarized in this chapter.",

keywords = "Endoplasmic reticulum, Kidney injury, Maladaptive response, Mitochondria, Organelle",

author = "Xuezhu Li and Feng Ding and Kyung Lee and He, {John Cijiang}",

note = "Publisher Copyright: {\textcopyright} 2022 Elsevier Inc.",

year = "2021",

month = jan,

day = "1",

doi = "10.1016/B978-0-12-823318-4.00033-0",

language = "English",

pages = "213--220",

booktitle = "Regenerative Nephrology",

publisher = "Elsevier",

address = "Netherlands",

}

TY - CHAP

T1 - Progression of kidney disease as a maladaptive response to injury

AU - Li, Xuezhu

AU - Ding, Feng

AU - Lee, Kyung

AU - He, John Cijiang

PY - 2021/1/1

Y1 - 2021/1/1

N2 - The kidney is vulnerable to acute kidney injury (AKI), the repair can make injury back to normal when minimal to mild, while also can be maladaptive when the damage is severe or persisted, and lead to chronic kidney disease (CKD). An organelle is a substructure that is directly related to various essential biological reactions within the cell, e.g., mitochondria, endoplasmic reticulum (ER), and lysosomes. Organelles stress and their crosstalk play an important role in the maladaptive response in various kidney injury. An elucidation of these mechanisms may help us to identify potential new therapeutic targets for both AKI and CKD. The role of organelles in mediating maladaptive response in kidney injury are summarized in this chapter.

AB - The kidney is vulnerable to acute kidney injury (AKI), the repair can make injury back to normal when minimal to mild, while also can be maladaptive when the damage is severe or persisted, and lead to chronic kidney disease (CKD). An organelle is a substructure that is directly related to various essential biological reactions within the cell, e.g., mitochondria, endoplasmic reticulum (ER), and lysosomes. Organelles stress and their crosstalk play an important role in the maladaptive response in various kidney injury. An elucidation of these mechanisms may help us to identify potential new therapeutic targets for both AKI and CKD. The role of organelles in mediating maladaptive response in kidney injury are summarized in this chapter.

KW - Endoplasmic reticulum

KW - Kidney injury

KW - Maladaptive response

KW - Mitochondria

KW - Organelle

UR - http://www.scopus.com/inward/record.url?scp=85127722548&partnerID=8YFLogxK

U2 - 10.1016/B978-0-12-823318-4.00033-0

DO - 10.1016/B978-0-12-823318-4.00033-0

M3 - Chapter

AN - SCOPUS:85127722548

SP - 213

EP - 220

BT - Regenerative Nephrology

PB - Elsevier

ER -

Progression of kidney disease as a maladaptive response to injury

Abstract

Keywords

Access to Document

Fingerprint

Cite this