Progression of kidney disease as a maladaptive response to injury

Xuezhu Li, Feng Ding, Kyung Lee, John Cijiang He

Research output: Chapter in Book/Report/Conference proceedingChapterpeer-review


The kidney is vulnerable to acute kidney injury (AKI), the repair can make injury back to normal when minimal to mild, while also can be maladaptive when the damage is severe or persisted, and lead to chronic kidney disease (CKD). An organelle is a substructure that is directly related to various essential biological reactions within the cell, e.g., mitochondria, endoplasmic reticulum (ER), and lysosomes. Organelles stress and their crosstalk play an important role in the maladaptive response in various kidney injury. An elucidation of these mechanisms may help us to identify potential new therapeutic targets for both AKI and CKD. The role of organelles in mediating maladaptive response in kidney injury are summarized in this chapter.

Original languageEnglish
Title of host publicationRegenerative Nephrology
Number of pages8
ISBN (Electronic)9780128233184
StatePublished - 1 Jan 2021


  • Endoplasmic reticulum
  • Kidney injury
  • Maladaptive response
  • Mitochondria
  • Organelle


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