@article{59ba40eb20774dc08c14232b3dbb8110,
title = "Progress in LRRK2-Associated Parkinson{\textquoteright}s Disease Animal Models",
abstract = "Mutations in the leucine-rich repeat kinase 2 (LRRK2) gene are the most frequent cause of familial Parkinson{\textquoteright}s disease (PD). Several genetic manipulations of the LRRK2 gene have been developed in animal models such as rodents, Drosophila, Caenorhabditis elegans, and zebrafish. These models can help us further understand the biological function and derive potential pathological mechanisms for LRRK2. Here we discuss common phenotypic themes found in LRRK2-associated PD animal models, highlight several issues that should be addressed in future models, and discuss emerging areas to guide their future development.",
keywords = "C. elegans, Drosophila, LRRK2, models, phenotypes, rodent, zebrafish",
author = "Seegobin, {Steven P.} and Heaton, {George R.} and Dongxiao Liang and Insup Choi and {Blanca Ramirez}, Marian and Beisha Tang and Zhenyu Yue",
note = "Funding Information: We would like to thank the Yue lab members for helpful discussions and our colleagues at the Icahn School of Medicine for their support. Funding. This work was supported by an NIH grant (R01NS06123, R01GM115844, and P50NS094733) to ZY. In addition, DL is supported by China Scholarship Council and MB is supported Fundaci{\'o}n Ram{\'o}n Areces. Publisher Copyright: {\textcopyright} Copyright {\textcopyright} 2020 Seegobin, Heaton, Liang, Choi, Blanca Ramirez, Tang and Yue.",
year = "2020",
month = jul,
day = "15",
doi = "10.3389/fnins.2020.00674",
language = "English",
volume = "14",
journal = "Frontiers in Neuroscience",
issn = "1662-4548",
publisher = "Frontiers Media S.A.",
}