TY - JOUR
T1 - Progress and Prospects in Pediatric Leukemia
AU - Madhusoodhan, P. Pallavi
AU - Carroll, William L.
AU - Bhatla, Teena
N1 - Publisher Copyright:
© 2016 Mosby, Inc.
PY - 2016/7/1
Y1 - 2016/7/1
N2 - Pediatric leukemia is the single most common malignancy affecting children, representing up to 30% of all pediatric cancers. Dramatic improvements in survival for acute lymphoblastic leukemia (ALL) have taken place over the past 4 decades with outcomes approaching 90% in the latest studies. However, progress has been slower for myeloid leukemia and certain subgroups like infant ALL, adolescent/young adult ALL, and relapsed ALL. Recent advances include recognition of molecularly defined subgroups, which has ushered in precision medicine approaches. We discuss the current understanding of the biology of the various childhood leukemias, recent advances in research, and future challenges in this field.
AB - Pediatric leukemia is the single most common malignancy affecting children, representing up to 30% of all pediatric cancers. Dramatic improvements in survival for acute lymphoblastic leukemia (ALL) have taken place over the past 4 decades with outcomes approaching 90% in the latest studies. However, progress has been slower for myeloid leukemia and certain subgroups like infant ALL, adolescent/young adult ALL, and relapsed ALL. Recent advances include recognition of molecularly defined subgroups, which has ushered in precision medicine approaches. We discuss the current understanding of the biology of the various childhood leukemias, recent advances in research, and future challenges in this field.
UR - http://www.scopus.com/inward/record.url?scp=84973138222&partnerID=8YFLogxK
U2 - 10.1016/j.cppeds.2016.04.003
DO - 10.1016/j.cppeds.2016.04.003
M3 - Article
C2 - 27283082
AN - SCOPUS:84973138222
SN - 1538-5442
VL - 46
SP - 229
EP - 241
JO - Current Problems in Pediatric and Adolescent Health Care
JF - Current Problems in Pediatric and Adolescent Health Care
IS - 7
ER -