Abstract
The value of morphometric analysis in addition to standard prognostic indicators was studied in 28 cases of papillary thyroid carcinoma. The mean follow up was 47 months. Recurrences occured in six patients at a mean time of 34 months, five with distal metastases and one with local disease. Univariate analysis most closely associated recurrence with nuclear anisotropism (the standard deviation of the estimated nuclear area (ENASD)) and tumor size. With forward stepwise incremental analysis, the value of tumor size was lost and only the ENASD and the cellularity mean index (CMI), defined as the percentage of tumor volume composed of tumor cells significantly correlated with recurrence. 55% of patients with a ENASD > 17μm2 and a CMI > 40% developed recurrence as compared to 5% of patients with lesser values (p=0.0001). Morphometric analysis may significantly contribute to the role of histopathology in the evaluation of papillary thyroid carcinoma and provide information regarding prognosis not obtained by standard methods.
| Original language | English |
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| Pages | 299-300 |
| Number of pages | 2 |
| State | Published - Nov 1988 |
| Externally published | Yes |
| Event | Proceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society - New Orleans, LA, USA Duration: 4 Nov 1988 → 7 Nov 1988 |
Conference
| Conference | Proceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society |
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| City | New Orleans, LA, USA |
| Period | 4/11/88 → 7/11/88 |