Prognostic significance of mucinous differentiation of endometrioid adenocarcinoma of the endometrium

Vijaya Galic; Maria B. Schiavone; Thomas J. Herzog; Kevin Holcomb; Sharyn N. Lewin; Yu Shiang Lu; Alfred I. Neugut; Dawn L. Hershman; Jason D. Wright

doi:10.3109/07357907.2013.820321

Prognostic significance of mucinous differentiation of endometrioid adenocarcinoma of the endometrium

Vijaya Galic, Maria B. Schiavone, Thomas J. Herzog, Kevin Holcomb, Sharyn N. Lewin, Yu Shiang Lu, Alfred I. Neugut, Dawn L. Hershman, Jason D. Wright

Research output: Contribution to journal › Article › peer-review

12 Scopus citations

Abstract

Using Surveillance, Epidemiology, and End Results database we identified 43,882 (97.0%) women with endometrioid adenocarcinomas and 1,374 (3.0%) with mucinous adenocarcinomas. Women with mucinous tumors were older (P < .0001), more often white (P = .04), and more often to present at advanced stage (P = .001). Survival was similar for both histologies; the hazard ratio for cancer-specific survival for mucinous compared to endometrioid tumors was 0.90 (95% CI, 0.74-1.09) while the hazard ratio for overall survival was 0.95 (95% CI, 0.85-1.07). Five-year survival for stage I mucinous tumors was 89.9% (95% CI, 87.6-91.9%) compared to 89.0% (95% CI, 88.6-89.4%) for endometrioid tumors.

Original language	English
Pages (from-to)	500-504
Number of pages	5
Journal	Cancer Investigation
Volume	31
Issue number	7
DOIs	https://doi.org/10.3109/07357907.2013.820321
State	Published - Aug 2013
Externally published	Yes

Keywords

Health sciences research
Other gynecologic tumors
Ovarian cancer

Access to Document

10.3109/07357907.2013.820321

Cite this

@article{a1b8d9a0d16041e19efc6af358155c75,

title = "Prognostic significance of mucinous differentiation of endometrioid adenocarcinoma of the endometrium",

abstract = "Using Surveillance, Epidemiology, and End Results database we identified 43,882 (97.0%) women with endometrioid adenocarcinomas and 1,374 (3.0%) with mucinous adenocarcinomas. Women with mucinous tumors were older (P < .0001), more often white (P = .04), and more often to present at advanced stage (P = .001). Survival was similar for both histologies; the hazard ratio for cancer-specific survival for mucinous compared to endometrioid tumors was 0.90 (95% CI, 0.74-1.09) while the hazard ratio for overall survival was 0.95 (95% CI, 0.85-1.07). Five-year survival for stage I mucinous tumors was 89.9% (95% CI, 87.6-91.9%) compared to 89.0% (95% CI, 88.6-89.4%) for endometrioid tumors.",

keywords = "Health sciences research, Other gynecologic tumors, Ovarian cancer",

author = "Vijaya Galic and Schiavone, {Maria B.} and Herzog, {Thomas J.} and Kevin Holcomb and Lewin, {Sharyn N.} and Lu, {Yu Shiang} and Neugut, {Alfred I.} and Hershman, {Dawn L.} and Wright, {Jason D.}",

note = "Funding Information: Dr. Wright (NCI R01CA169121–01A1) and Dr. Hershman (NCI R01CA134964) are recipients of grants from the National Cancer Institute.",

year = "2013",

month = aug,

doi = "10.3109/07357907.2013.820321",

language = "English",

volume = "31",

pages = "500--504",

journal = "Cancer Investigation",

issn = "0735-7907",

publisher = "Informa Healthcare",

number = "7",

}

TY - JOUR

T1 - Prognostic significance of mucinous differentiation of endometrioid adenocarcinoma of the endometrium

AU - Galic, Vijaya

AU - Schiavone, Maria B.

AU - Herzog, Thomas J.

AU - Holcomb, Kevin

AU - Lewin, Sharyn N.

AU - Lu, Yu Shiang

AU - Neugut, Alfred I.

AU - Hershman, Dawn L.

AU - Wright, Jason D.

N1 - Funding Information: Dr. Wright (NCI R01CA169121–01A1) and Dr. Hershman (NCI R01CA134964) are recipients of grants from the National Cancer Institute.

PY - 2013/8

Y1 - 2013/8

N2 - Using Surveillance, Epidemiology, and End Results database we identified 43,882 (97.0%) women with endometrioid adenocarcinomas and 1,374 (3.0%) with mucinous adenocarcinomas. Women with mucinous tumors were older (P < .0001), more often white (P = .04), and more often to present at advanced stage (P = .001). Survival was similar for both histologies; the hazard ratio for cancer-specific survival for mucinous compared to endometrioid tumors was 0.90 (95% CI, 0.74-1.09) while the hazard ratio for overall survival was 0.95 (95% CI, 0.85-1.07). Five-year survival for stage I mucinous tumors was 89.9% (95% CI, 87.6-91.9%) compared to 89.0% (95% CI, 88.6-89.4%) for endometrioid tumors.

AB - Using Surveillance, Epidemiology, and End Results database we identified 43,882 (97.0%) women with endometrioid adenocarcinomas and 1,374 (3.0%) with mucinous adenocarcinomas. Women with mucinous tumors were older (P < .0001), more often white (P = .04), and more often to present at advanced stage (P = .001). Survival was similar for both histologies; the hazard ratio for cancer-specific survival for mucinous compared to endometrioid tumors was 0.90 (95% CI, 0.74-1.09) while the hazard ratio for overall survival was 0.95 (95% CI, 0.85-1.07). Five-year survival for stage I mucinous tumors was 89.9% (95% CI, 87.6-91.9%) compared to 89.0% (95% CI, 88.6-89.4%) for endometrioid tumors.

KW - Health sciences research

KW - Other gynecologic tumors

KW - Ovarian cancer

UR - http://www.scopus.com/inward/record.url?scp=84881309365&partnerID=8YFLogxK

U2 - 10.3109/07357907.2013.820321

DO - 10.3109/07357907.2013.820321

M3 - Article

C2 - 23915075

AN - SCOPUS:84881309365

SN - 0735-7907

VL - 31

SP - 500

EP - 504

JO - Cancer Investigation

JF - Cancer Investigation

IS - 7

ER -

Prognostic significance of mucinous differentiation of endometrioid adenocarcinoma of the endometrium

Abstract

Keywords

Access to Document

Fingerprint

Cite this