Prognostic significance of DNA content abnormalities in young patients with colorectal cancer

T. M. Heimann, G. Martinelli, A. Szporn, R. J. Kurtz, A. Quish, F. Miller, S. C. Oh, T. Fasy

Research output: Contribution to journalArticlepeer-review

17 Scopus citations

Abstract

Several studies have shown that the presence of DNA ploidy abnormalities, measured by flow cytometry, may correlate with a poor prognosis in a variety of cancers. The predictive value of these DNA abnormalities in young patients with colorectal cancer has not been well studied. Fifty patients aged 40 years and younger with colorectal adenocarcinoma were studied to determine the correlation of tumor DNA abnormalities with survival. DNA content was determined by flow cytometric analysis and each tumor was categorized as diploid or nondiploid. Of the parameters studied, Dukes' classification and tumor DNA ploidy were found to be significant prognostic indicators. Determination of DNA content seems to provide additional useful prognostic information in young patients with colorectal cancer.

Original languageEnglish
Pages (from-to)792-795
Number of pages4
JournalAnnals of Surgery
Volume210
Issue number6
StatePublished - 1989
Externally publishedYes

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