TY - JOUR
T1 - Prognostic importance of the serum magnesium concentration in patients with congestive heart failure
AU - Gottlieb, Stephen S.
AU - Baruch, Lawrence
AU - Kukin, Marrick L.
AU - Bernstein, Jonine L.
AU - Packer, Milton
N1 - Funding Information:
From the Division of Cardiology. The Mount Sinai School of Medicine. New York, New York and the *Division of Cardiology, University of Maryland School of Medicine. Baltimore. Maryland. This study was supported in part by Grants ROI-HL-25055 and K04-HL-01229 from the National Heart, Lung, and Blood Institute, National Institutes of Health. Bethesda, Maryland. Dr. Packer is the recipient of a Research Career Development Award from the National Institutes of Health. This study was presented in part at the 1989 National Meeting of the American Federation of Clinical Research. Washington, D.C.
PY - 1990
Y1 - 1990
N2 - Magnesium abnormalities are common in patients with congestive heart failure but the clinical and prognostic significance of an abnormal serum magnesium concentration in this disorder has not been investigated. Therefore, the relation between serum magnesium concentration and the clinical characteristics and long-term outcome of 199 patients with chronic heart failure was evaluated. The serum magnesium concentration was <1.6 mEq/liter in 38 patients (19%), within the normal range in 134 patients (67%) and >2.1 mEq/liter in 27 patients (14%). Patients with hypomagnesemia had more frequent ventricular premature complexes and episodes of ventricular tachycardia than did patients with a normal serum magnesium concentration (p < 0.05). Even though the two groups were similar with respect to severity of heart failure and neurohormonal variables, patients with a low serum magnesium concentration had a significantly worse prognosis during long-term follow-up (45% versus 71% 1 year survival, p < 0.05). Patients with hypermagnesemia had more severe symptoms, greater neurohormonal activation and worse renal function than did patients with a normal serum magnesium concentration but tended to have fewer ventricular arrhythmias. Hypermagnesemic patients had a worse prognosis than did those with a normal magnesium concentration (37% versus 71% 1 year survival, p < 0.05). In conclusion, the measurement of serum magnesium concentration provides important clinical and prognostic information in patients with chronic heart failure.
AB - Magnesium abnormalities are common in patients with congestive heart failure but the clinical and prognostic significance of an abnormal serum magnesium concentration in this disorder has not been investigated. Therefore, the relation between serum magnesium concentration and the clinical characteristics and long-term outcome of 199 patients with chronic heart failure was evaluated. The serum magnesium concentration was <1.6 mEq/liter in 38 patients (19%), within the normal range in 134 patients (67%) and >2.1 mEq/liter in 27 patients (14%). Patients with hypomagnesemia had more frequent ventricular premature complexes and episodes of ventricular tachycardia than did patients with a normal serum magnesium concentration (p < 0.05). Even though the two groups were similar with respect to severity of heart failure and neurohormonal variables, patients with a low serum magnesium concentration had a significantly worse prognosis during long-term follow-up (45% versus 71% 1 year survival, p < 0.05). Patients with hypermagnesemia had more severe symptoms, greater neurohormonal activation and worse renal function than did patients with a normal serum magnesium concentration but tended to have fewer ventricular arrhythmias. Hypermagnesemic patients had a worse prognosis than did those with a normal magnesium concentration (37% versus 71% 1 year survival, p < 0.05). In conclusion, the measurement of serum magnesium concentration provides important clinical and prognostic information in patients with chronic heart failure.
UR - https://www.scopus.com/pages/publications/0025172187
U2 - 10.1016/S0735-1097(10)80329-8
DO - 10.1016/S0735-1097(10)80329-8
M3 - Article
C2 - 2212365
AN - SCOPUS:0025172187
SN - 0735-1097
VL - 16
SP - 827
EP - 831
JO - Journal of the American College of Cardiology
JF - Journal of the American College of Cardiology
IS - 4
ER -