Prognostic and Predictive Biomarkers in Oligometastatic Disease

Kevin J. Barnum, Sarah A. Weiss

Research output: Contribution to journalReview articlepeer-review

7 Scopus citations

Abstract

Metastatic lesions are largely responsible for cancer-related deaths and are synonymous with a poor prognosis. However, this is not always true for patients with oligometastases whose disease may be amenable to curative-intent local therapies. It has been proposed that an "intermediate state"(oligometastasis) exists in between locoregional and advanced disease states; however, the clinical definition of oligometastasis varies, and there is limited understanding of how tumor biology differs between oligometastases and polymetastases. There is evidence that local therapies can extend survival in patients with oligometastases, yet patient selection for local intervention and/or systemic therapy remains a challenge. Prognostic and predictive biomarkers of oligometastatic disease are strongly needed to identify patient candidates most likely to gain survival benefit from local therapies and to aid in the incorporation of ablative treatments in the context of existing systemic therapies.

Original languageEnglish
Pages (from-to)100-107
Number of pages8
JournalCancer journal (Sudbury, Mass.)
Volume26
Issue number2
DOIs
StatePublished - 1 Mar 2020
Externally publishedYes

Keywords

  • Ablative therapy
  • biomarkers
  • oligometastases
  • predictive
  • prognostic

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