TY - JOUR
T1 - Prognosis of patients with non-ST-segment-elevation myocardial infarction and nonobstructive coronary artery disease
T2 - Propensity-matched analysis from the acute catheterization and urgent intervention triage strategy trial
AU - Planer, David
AU - Mehran, Roxana
AU - Ohman, E. Magnus
AU - White, Harvey D.
AU - Newman, Jonathan D.
AU - Xu, Ke
AU - Stone, Gregg W.
PY - 2014/6
Y1 - 2014/6
N2 - Background-Troponin elevation is a risk factor for mortality in patients with non-ST-segment-elevation acute coronary syndromes. However, the prognosis of patients with troponin elevation and nonobstructive coronary artery disease (CAD) is unknown. Our objective was therefore to evaluate the impact of nonobstructive CAD in patients with non-ST-segment-elevation acute coronary syndromes and troponin elevation enrolled in the Acute Catheterization and Urgent Intervention Triage Strategy (ACUITY) trial. Methods and Results-In the ACUITY trial, 3-vessel quantitative coronary angiography was performed in a formal substudy of 6921 patients presenting with non-ST-segment-elevation acute coronary syndromes. Patients with elevated admission troponin levels were stratifed by the presence or absence of obstructive CAD (any lesion with quantitative diameter stenosis >50%). Propensity score matching was performed to adjust for baseline characteristics. Of 2442 patients with elevated troponin, 197 (8.8%) had nonobstructive CAD. Maximum diameter stenosis was 87.4 (73.2, 100.0) versus 22.6 (19.2, 25.7; P<0.0001) in patients with versus without obstructive CAD, respectively. Propensity matching yielded 117 patients with nonobstructive CAD and 331 patients with obstructive CAD, with no signifcant baseline differences between groups. In the matched cohort, overall 1-year mortality was signifcantly higher in patients with nonobstructive CAD (5.2% versus 1.6%; hazard ratio [95% confdence interval]=3.44 [1.05, 11.28]; P=0.04), driven by greater noncardiac mortality. Conversely, recurrent myocardial infarction and unplanned revascularization rates were signifcantly higher in patients with obstructive CAD. Conclusions-Patients with non-ST-segment-elevation acute coronary syndromes and elevated troponin levels but without obstructive CAD, while having low rates of subsequent myocardial infarction and unplanned revascularization, are still at considerable risk for 1-year mortality from noncardiac causes.
AB - Background-Troponin elevation is a risk factor for mortality in patients with non-ST-segment-elevation acute coronary syndromes. However, the prognosis of patients with troponin elevation and nonobstructive coronary artery disease (CAD) is unknown. Our objective was therefore to evaluate the impact of nonobstructive CAD in patients with non-ST-segment-elevation acute coronary syndromes and troponin elevation enrolled in the Acute Catheterization and Urgent Intervention Triage Strategy (ACUITY) trial. Methods and Results-In the ACUITY trial, 3-vessel quantitative coronary angiography was performed in a formal substudy of 6921 patients presenting with non-ST-segment-elevation acute coronary syndromes. Patients with elevated admission troponin levels were stratifed by the presence or absence of obstructive CAD (any lesion with quantitative diameter stenosis >50%). Propensity score matching was performed to adjust for baseline characteristics. Of 2442 patients with elevated troponin, 197 (8.8%) had nonobstructive CAD. Maximum diameter stenosis was 87.4 (73.2, 100.0) versus 22.6 (19.2, 25.7; P<0.0001) in patients with versus without obstructive CAD, respectively. Propensity matching yielded 117 patients with nonobstructive CAD and 331 patients with obstructive CAD, with no signifcant baseline differences between groups. In the matched cohort, overall 1-year mortality was signifcantly higher in patients with nonobstructive CAD (5.2% versus 1.6%; hazard ratio [95% confdence interval]=3.44 [1.05, 11.28]; P=0.04), driven by greater noncardiac mortality. Conversely, recurrent myocardial infarction and unplanned revascularization rates were signifcantly higher in patients with obstructive CAD. Conclusions-Patients with non-ST-segment-elevation acute coronary syndromes and elevated troponin levels but without obstructive CAD, while having low rates of subsequent myocardial infarction and unplanned revascularization, are still at considerable risk for 1-year mortality from noncardiac causes.
KW - Acute coronary syndrome
KW - Prognosis
KW - Propensity score
KW - Troponin
UR - http://www.scopus.com/inward/record.url?scp=84905859597&partnerID=8YFLogxK
U2 - 10.1161/CIRCINTERVENTIONS.113.000606
DO - 10.1161/CIRCINTERVENTIONS.113.000606
M3 - Article
C2 - 24847016
AN - SCOPUS:84905859597
SN - 1941-7640
VL - 7
SP - 285
EP - 293
JO - Circulation: Cardiovascular Interventions
JF - Circulation: Cardiovascular Interventions
IS - 3
ER -