TY - JOUR
T1 - Profiling the lymphoid-resident T cell pool reveals modulation by age and microbiota
AU - Durand, Aurélie
AU - Audemard-Verger, Alexandra
AU - Guichard, Vincent
AU - Mattiuz, Raphaël
AU - Delpoux, Arnaud
AU - Hamon, Pauline
AU - Bonilla, Nelly
AU - Rivière, Matthieu
AU - Delon, Jérôme
AU - Martin, Bruno
AU - Auffray, Cédric
AU - Boissonnas, Alexandre
AU - Lucas, Bruno
N1 - Publisher Copyright:
© 2017 The Author(s).
PY - 2018/12/1
Y1 - 2018/12/1
N2 - Despite being implicated in non-lymphoid tissues, non-recirculating T cells may also exist in secondary lymphoid organs (SLO). However, a detailed characterization of this lymphoid-resident T cell pool has not yet been done. Here we show that a substantial proportion of CD4 regulatory (Treg) and memory (Tmem) cells establish long-term residence in the SLOs of specific pathogen-free mice. Of these SLOs, only T cell residence within Peyer's patches is affected by microbiota. Resident CD4 Treg and CD4 Tmem cells from lymph nodes and non-lymphoid tissues share many phenotypic and functional characteristics. The percentage of resident T cells in SLOs increases considerably with age, with S1PR1 downregulation possibly contributing to this altered homeostasis. Our results thus show that T cell residence is not only a hallmark of non-lymphoid tissues, but can be extended to secondary lymphoid organs.
AB - Despite being implicated in non-lymphoid tissues, non-recirculating T cells may also exist in secondary lymphoid organs (SLO). However, a detailed characterization of this lymphoid-resident T cell pool has not yet been done. Here we show that a substantial proportion of CD4 regulatory (Treg) and memory (Tmem) cells establish long-term residence in the SLOs of specific pathogen-free mice. Of these SLOs, only T cell residence within Peyer's patches is affected by microbiota. Resident CD4 Treg and CD4 Tmem cells from lymph nodes and non-lymphoid tissues share many phenotypic and functional characteristics. The percentage of resident T cells in SLOs increases considerably with age, with S1PR1 downregulation possibly contributing to this altered homeostasis. Our results thus show that T cell residence is not only a hallmark of non-lymphoid tissues, but can be extended to secondary lymphoid organs.
UR - https://www.scopus.com/pages/publications/85040230849
U2 - 10.1038/s41467-017-02458-4
DO - 10.1038/s41467-017-02458-4
M3 - Article
C2 - 29302034
AN - SCOPUS:85040230849
SN - 2041-1723
VL - 9
JO - Nature Communications
JF - Nature Communications
IS - 1
M1 - 68
ER -