Production of infectious Epstein-Barr virus in mouse lymphocytes

David J. Volsky, George Klein, Barbara Volsky, Ilya M. Shapiro

Research output: Contribution to journalArticlepeer-review

23 Scopus citations

Abstract

Most studies of the course of primary infection by Epstein-Barr virus (EBV, associated with Burkitt's lymphoma and naso-pharyngeal carcinoma1,2) have been made with human and other primate B lymphocytes, the chief naturally susceptible host cell type3. In vitro infection of B lymphocytes results, however, in their transformation into permanent lymphoid cell types in which the lytic cycle is virtually suppressed. Infection of B lymphocytes is sharply restricted to those cells that carry surface receptors for immunoglobin and the C3 component of complement. Infectibility may be entirely determined by the presence of EBV virus receptors, which is itself closely correlated with the presence of receptors for B cell-specific complement (C3d), but the establishment of the latent transformed state of host cells may well involve other internal characteristics of the differentiated B cell. We now report that, by means of the technique for implanting EBV receptors into the membranes of cells that lack them4, mouse lymphocytes can be infected with EBV resulting in a complete viral cycle, not in a state of latent transformation.

Original languageEnglish
Pages (from-to)399-401
Number of pages3
JournalNature
Volume293
Issue number5831
DOIs
StatePublished - 1981
Externally publishedYes

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