Procedural results and early clinical outcome of percutaneous transluminal myocardial revascularization

Fayaz A. Shawl, Michael J. Domanski, Upendra Kaul, Kathy G. Dougherty, Susan Hoff, Gina E. Rigali, Stephanie L. Cornell, S. Tariq Shahab

Research output: Contribution to journalArticlepeer-review

35 Scopus citations

Abstract

A substantial number of patients present with medically refractory angina who are not candidates for angioplasty or bypass surgery. The creation of channels between the myocardium and the ventricular blood pool has been performed after thoracotomy with excellent relief of symptoms but has been associated with high perioperative mortality. We investigated the safely of a nonoperative, percutaneous technique for channel creation. Twenty-seven patients with angina and coronary anatomy not amenable to revascularization with coronary angioplasty or bypass surgery underwent percutaneous transluminal myocardial revascularization (PTMR). Energy from a Holmium:yttrium-aluminum-garnet (YAG) laser was directed through a fiber enclosed in a catheter to the ventricular myocardium creating channels between the blood pool and the myocardium. On average, 17 ± 4 channels were formed per patient. There were no procedure-related deaths, episodes of tamponade, or other complications except for an increase in creatine phosphokinase in 1 patient. Immediately after the procedure, there was no worsening of regional wall motion function in any patient, but rather improvement in some. All patients were discharged alive after a hospital stay of 1.8 ± 1.5 days. Mean Canadian Cardiovascular Society functional class declined from 3.6 ± 0.5 before the procedure to 0.65 ± 0.8 at 30 days after the procedure (p ≤0.01). For 12 patients eligible for 6-month follow-up, mean functional class was 0.94 ± 0.97. At 6-month stress testing, 9 of these 12 had no electrocardiographic evidence of ischemia. Thus, PTMR can be performed safely in the cardiac catheterization laboratory with a complication rate lower than that reported in surgical series and with excellent near-term symptomatic relief. The long-term effect of PTMR on mortality and relief of angina as well as its safety and effectiveness compared with the surgical approach remains to be defined.

Original languageEnglish
Pages (from-to)498-501
Number of pages4
JournalAmerican Journal of Cardiology
Volume83
Issue number4
DOIs
StatePublished - 15 Feb 1999

Fingerprint

Dive into the research topics of 'Procedural results and early clinical outcome of percutaneous transluminal myocardial revascularization'. Together they form a unique fingerprint.

Cite this