Cell-restricted transcriptional modulators play a crucial role in the process of selective gene regulation during hematopoiesis. Erythroid Krüppel-like factor (EKLF; KLF1) is a transcription factor, originally identified in this laboratory, which plays a crucial role as a transcriptional activator at the adult β-globin locus. This review will describe a subset of experiments and approaches related to deciphering its mechanism of action and the means by which it itself is induced.

Original languageEnglish
Pages (from-to)333-338
Number of pages6
JournalMount Sinai Journal of Medicine
Issue number5
StatePublished - 2005


  • EKLF
  • Erythroid cell
  • Gene regulation
  • Transcription


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