TY - GEN
T1 - Probing organic-mineral interface in intact bone using magic angle spinning solid state NMR
AU - Nikel, O.
AU - Laurencin, D.
AU - Besdos, S.
AU - Vashishth, D.
PY - 2011
Y1 - 2011
N2 - Organic-mineral interface plays an important role in defining the mechanical properties of bone. Ability to probe this poorly understood interface at the molecular level in intact bone is desirable, and solid state NMR is one of the few techniques available for this. An intact cortical bone was successfully machined and spun at 12.5kHz. The 13C-31P REDOR pulse sequence was used on a powdered bovine bone to mark carbon environments that are spatially proximate to the surface of mineral phase, thereby giving direct insight on the structure of the organic-mineral interface.
AB - Organic-mineral interface plays an important role in defining the mechanical properties of bone. Ability to probe this poorly understood interface at the molecular level in intact bone is desirable, and solid state NMR is one of the few techniques available for this. An intact cortical bone was successfully machined and spun at 12.5kHz. The 13C-31P REDOR pulse sequence was used on a powdered bovine bone to mark carbon environments that are spatially proximate to the surface of mineral phase, thereby giving direct insight on the structure of the organic-mineral interface.
UR - http://www.scopus.com/inward/record.url?scp=79958756707&partnerID=8YFLogxK
U2 - 10.1109/NEBC.2011.5778686
DO - 10.1109/NEBC.2011.5778686
M3 - Conference contribution
AN - SCOPUS:79958756707
SN - 9781612848273
T3 - 2011 IEEE 37th Annual Northeast Bioengineering Conference, NEBEC 2011
BT - 2011 IEEE 37th Annual Northeast Bioengineering Conference, NEBEC 2011
T2 - 37th Annual Northeast Bioengineering Conference, NEBEC 2011
Y2 - 1 April 2011 through 3 April 2011
ER -