PRMT5 function and targeting in cancer

Hyungsoo Kim, Ze'ev A. Ronai

Research output: Contribution to journalReview articlepeer-review

78 Scopus citations


Protein methyl transferases play critical roles in numerous regulatory pathways that underlie cancer development, progression and therapyresponse. Here we discuss the function of PRMT5, a member of the nine-member PRMT family, in controlling oncogenic processes including tumor intrinsic, as well as extrinsic microenvironmental signaling pathways. We discuss PRMT5 effect on histone methylation and methylation of regulatory proteins including those involved in RNA splicing, cell cycle, cell death and metabolic signaling. In all, we highlight the importance of PRMT5 regulation and function in cancer, which provide the foundation for therapeutic modalities targeting PRMT5.

Original languageEnglish
Pages (from-to)199-215
Number of pages17
JournalCell Stress
Issue number8
StatePublished - Aug 2020
Externally publishedYes


  • Histone
  • MEP50
  • Methylation
  • Methyltransferase
  • PRMT1
  • PRMT5
  • Splicing
  • Transcription


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