Priorities and Progress in Gram-positive Bacterial Infection Research by the Antibacterial Resistance Leadership Group: A Narrative Review

Sarah B. Doernberg, Cesar A. Arias, Deena R. Altman, Ahmed Babiker, Helen W. Boucher, C. Buddy Creech, Sara E. Cosgrove, Scott R. Evans, Vance G. Fowler, Stephanie A. Fritz, Toshimitsu Hamasaki, Brendan J. Kelly, Sixto M. Leal, Catherine Liu, Thomas P. Lodise, Loren G. Miller, Jose M. Munita, Barbara E. Murray, Melinda M. Pettigrew, Felicia RuffinMarc H. Scheetz, Bo Shopsin, Truc T. Tran, Nicholas A. Turner, Derek J. Williams, Smitha Zaharoff, Thomas L. Holland

Research output: Contribution to journalArticlepeer-review

2 Scopus citations

Abstract

The Antibacterial Resistance Leadership Group (ARLG) has prioritized infections caused by gram-positive bacteria as one of its core areas of emphasis. The ARLG Gram-positive Committee has focused on studies responding to 3 main identified research priorities: (1) investigation of strategies or therapies for infections predominantly caused by gram-positive bacteria, (2) evaluation of the efficacy of novel agents for infections caused by methicillin-resistant Staphylococcus aureus (MRSA) and vancomycin-resistant enterococci, and (3) optimization of dosing and duration of antimicrobial agents for gram-positive infections. Herein, we summarize ARLG accomplishments in gram-positive bacterial infection research, including studies aiming to (1) inform optimal vancomycin dosing, (2) determine the role of dalbavancin in MRSA bloodstream infection, (3) characterize enterococcal bloodstream infections, (4) demonstrate the benefits of short-course therapy for pediatric community-acquired pneumonia, (5) develop quality of life measures for use in clinical trials, and (6) advance understanding of the microbiome. Future studies will incorporate innovative methodologies with a focus on interventional clinical trials that have the potential to change clinical practice for difficult-to-treat infections, such as MRSA bloodstream infections.

Original languageEnglish
Pages (from-to)S295-S304
JournalClinical Infectious Diseases
Volume77
DOIs
StatePublished - 15 Oct 2023

Keywords

  • antibacterial agents
  • antibacterial resistance
  • gram-positive bacterial infections
  • methicillin-resistant Staphylococcus aureus
  • vancomycin-resistant enterococci

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