Abstract
Primary sclerosing cholangitis (PSC) is a chronic inflammatory condition affecting the biliary tree, characterized by stricturing and dilation of intra- and/or extrahepatic bile ducts. While the etiology remains unknown, a strong association with inflammatory bowel disease is observed. PSC's variable natural history involves cholangitis episodes, biliary cirrhosis, and a heightened risk of cholangiocarcinoma (CCA). Currently, there are no effective medical therapies for PSC, but endoscopic interventions offer temporary relief and aid in diagnosing CCA. Liver transplantation stands as the optimal treatment for advanced PSC-related liver disease, boasting excellent long-term survival, despite a potential risk of recurrent PSC post-transplant.
| Original language | English |
|---|---|
| Title of host publication | Hepatology |
| Subtitle of host publication | an Evidence-Based Clinical Compendium: Volume 1-2 |
| Publisher | Elsevier |
| Pages | 531-560 |
| Number of pages | 30 |
| Volume | 1-2 |
| ISBN (Electronic) | 9780443300523 |
| ISBN (Print) | 9780443300530 |
| DOIs | |
| State | Published - 1 Jan 2024 |
Keywords
- Biliary cirrhosis
- Cholangiocarcinoma
- Cholangitis
- Endoscopic treatment
- Inflammatory bowel disease
- Liver transplantation
- Primary sclerosing cholangitis
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