Primary Neuroendocrine Carcinoma of the Breast Metastatic to the Bones, Which Chemotherapy?

Aye M. Soe, Gardith Joseph, Elizabeth Guevara, Philip Xiao

Research output: Contribution to journalArticlepeer-review

4 Scopus citations

Abstract

The primary neuroendocrine carcinoma (NEC) of the breast is defined as immunohistochemical expression of neuroendocrine markers (chromogranin and synoptophysin) in more than 50% of the neoplastic cells according to World Health Organization (WHO) classification of tumors in 2003 (Tumours of the Breast and Female Genital Organs, 2003, Lyon: IARC Press). It accounts for less than 5% of all cancers arising from the breast (Tumours of the Breast and Female Genital Organs, 2003, Lyon, France: IARC Press). However, based on the study conducted by Wang et al., the primary NEC of breast comprises less than 0.1% of all mammary carcinomas (Frankf Z Pathol, 73, 1963, 24). Because of the rarity of the disease and absence of the prospective trials, there is no standard treatment for primary NEC of the breast. Herein, we report the case of a middle age woman with primary NEC with bone metastasis.

Original languageEnglish
Pages (from-to)589-593
Number of pages5
JournalBreast Journal
Volume23
Issue number5
DOIs
StatePublished - Sep 2017
Externally publishedYes

Keywords

  • chromogranin
  • neuroendocrine carcinoma
  • synaptophysin

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