TY - JOUR
T1 - Primary dural mucosa-associated lymphoid tissue-type lymphoma
T2 - Case report and review of the literature
AU - Rottnek, M.
AU - Strauchen, J.
AU - Moore, F.
AU - Morgello, Susan
PY - 2004/5
Y1 - 2004/5
N2 - A 47-year-old Hispanic male presented with visual field disturbances, memory impairment, and a seizure. CT and MRI were consistent with meningioma. Both neurologic exam and routine laboratory tests were within normal limits. The patient underwent craniotomy and subtotal resection of the tumor. On H&E, the lesion was composed of a lymphoid mass with well-defined irregularly shaped follicles surrounded by a monomorphic population of small lymphocytes. Marginal zones stained for B-cell markers, CD20 and CD79a, one T-cell marker, CD43, and kappa light chains. While other markers did not stain the majority of tumor cells, they did identify other lymphoid and plasma cell elements. A diagnosis of marginal zone B-cell lymphoma of dura, mucosa-associated lymphoid tissue (MALT)-type (extranodal) was made. MALT-type lymphomas are unusual in the nervous system; this is the first such case reported in a male and serves to emphasize the wide diversity of presentation of a neoplasm originally described in the GI tract and thus far described in the CNS only in females.
AB - A 47-year-old Hispanic male presented with visual field disturbances, memory impairment, and a seizure. CT and MRI were consistent with meningioma. Both neurologic exam and routine laboratory tests were within normal limits. The patient underwent craniotomy and subtotal resection of the tumor. On H&E, the lesion was composed of a lymphoid mass with well-defined irregularly shaped follicles surrounded by a monomorphic population of small lymphocytes. Marginal zones stained for B-cell markers, CD20 and CD79a, one T-cell marker, CD43, and kappa light chains. While other markers did not stain the majority of tumor cells, they did identify other lymphoid and plasma cell elements. A diagnosis of marginal zone B-cell lymphoma of dura, mucosa-associated lymphoid tissue (MALT)-type (extranodal) was made. MALT-type lymphomas are unusual in the nervous system; this is the first such case reported in a male and serves to emphasize the wide diversity of presentation of a neoplasm originally described in the GI tract and thus far described in the CNS only in females.
KW - CNS MALToma
KW - Dural lymphoma
UR - http://www.scopus.com/inward/record.url?scp=2942748273&partnerID=8YFLogxK
U2 - 10.1023/B:NEON.0000024704.70250.42
DO - 10.1023/B:NEON.0000024704.70250.42
M3 - Article
C2 - 15174517
AN - SCOPUS:2942748273
SN - 0167-594X
VL - 68
SP - 19
EP - 23
JO - Journal of Neuro-Oncology
JF - Journal of Neuro-Oncology
IS - 1
ER -