Primary central nervous system lymphoma in childhood presenting as progressive panhypopituitarism

Miriam E. Silfen, James H. Garvin, Arthur P. Hays, Harold S. Starkman, Gaya S. Aranoff, Lenore S. Levine, Neil A. Feldstein, Brian Wong, Sharon E. Oberfield

Research output: Contribution to journalArticlepeer-review

38 Scopus citations


We report a 15-year-old boy who had isolated central diabetes insipidus initially diagnosed at age 11 years. A brain magnetic resonance imaging (MRI) was normal at the time. At age 12 years, growth hormone (GH) testing was performed because of a decline in linear growth rate and demonstrated GH deficiency. After a repeat normal brain MRI, GH therapy was begun. Three years later, hormonal testing revealed prepubertal gonadotropins and low testosterone levels, free thyroxine index, and morning cortisol levels. Repeat brain MRI demonstrated a 9-mm enhancing lesion in the region of the pituitary stalk. The pathologic diagnosis was that of a high-grade malignant B-cell lymphoma, suggestive of Burkitt lymphoma. Growth hormone therapy has not been associated with an increased incidence of lymphoma. This report underscores the need for vigilance in follow-up brain imaging and hormonal evaluation in children with diabetes insipidus, especially those with evolving anterior hormone deficiencies.

Original languageEnglish
Pages (from-to)130-133
Number of pages4
JournalAmerican Journal of Pediatric Hematology/Oncology
Issue number2
StatePublished - 2001
Externally publishedYes


  • Diabetes insipidus
  • Growth hormone therapy
  • Panhypopituitarism
  • Primary CNS lymphoma


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