Primary brain tumors, neural stem cell, and brain tumor cancer cells: Where is the link?

Isabelle Germano; Victoria Swiss; Patrizia Casaccia

doi:10.1016/j.neuropharm.2009.12.019

Primary brain tumors, neural stem cell, and brain tumor cancer cells: Where is the link?

Isabelle Germano, Victoria Swiss, Patrizia Casaccia

Research output: Contribution to journal › Review article › peer-review

49 Scopus citations

Abstract

The discovery of brain tumor-derived cells (BTSC) with the properties of stem cells has led to the formulation of the hypothesis that neural stem cells could be the cell of origin of primary brain tumors (PBT). In this review we present the most common molecular changes in PBT, define the criteria of identification of BTSC and discuss the similarities between the characteristics of these cells and those of the endogenous population of neural stem cells (NPCs) residing in germinal areas of the adult brain. Finally, we propose possible mechanisms of cancer initiation and progression and suggest a model of tumor initiation that includes intrinsic changes of resident NSC and potential changes in the microenvironment defining the niche where the NSC reside.

Original language	English
Pages (from-to)	903-910
Number of pages	8
Journal	Neuropharmacology
Volume	58
Issue number	6
DOIs	https://doi.org/10.1016/j.neuropharm.2009.12.019
State	Published - May 2010

Keywords

Cancer
Epigenetics
Glioblastoma
Proliferation
Stem cells

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10.1016/j.neuropharm.2009.12.019

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title = "Primary brain tumors, neural stem cell, and brain tumor cancer cells: Where is the link?",

abstract = "The discovery of brain tumor-derived cells (BTSC) with the properties of stem cells has led to the formulation of the hypothesis that neural stem cells could be the cell of origin of primary brain tumors (PBT). In this review we present the most common molecular changes in PBT, define the criteria of identification of BTSC and discuss the similarities between the characteristics of these cells and those of the endogenous population of neural stem cells (NPCs) residing in germinal areas of the adult brain. Finally, we propose possible mechanisms of cancer initiation and progression and suggest a model of tumor initiation that includes intrinsic changes of resident NSC and potential changes in the microenvironment defining the niche where the NSC reside.",

keywords = "Cancer, Epigenetics, Glioblastoma, Proliferation, Stem cells",

author = "Isabelle Germano and Victoria Swiss and Patrizia Casaccia",

note = "Funding Information: Patrizia Casaccia acknowledges the support of NIH-NINDS R01NS42925–07 and R01NS052738-04 Isabelle Germano acknowledges the support of NIH/NCI 1RO1 CA129489-01.",

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T1 - Primary brain tumors, neural stem cell, and brain tumor cancer cells

T2 - Where is the link?

AU - Germano, Isabelle

AU - Swiss, Victoria

AU - Casaccia, Patrizia

N1 - Funding Information: Patrizia Casaccia acknowledges the support of NIH-NINDS R01NS42925–07 and R01NS052738-04 Isabelle Germano acknowledges the support of NIH/NCI 1RO1 CA129489-01.

PY - 2010/5

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N2 - The discovery of brain tumor-derived cells (BTSC) with the properties of stem cells has led to the formulation of the hypothesis that neural stem cells could be the cell of origin of primary brain tumors (PBT). In this review we present the most common molecular changes in PBT, define the criteria of identification of BTSC and discuss the similarities between the characteristics of these cells and those of the endogenous population of neural stem cells (NPCs) residing in germinal areas of the adult brain. Finally, we propose possible mechanisms of cancer initiation and progression and suggest a model of tumor initiation that includes intrinsic changes of resident NSC and potential changes in the microenvironment defining the niche where the NSC reside.

AB - The discovery of brain tumor-derived cells (BTSC) with the properties of stem cells has led to the formulation of the hypothesis that neural stem cells could be the cell of origin of primary brain tumors (PBT). In this review we present the most common molecular changes in PBT, define the criteria of identification of BTSC and discuss the similarities between the characteristics of these cells and those of the endogenous population of neural stem cells (NPCs) residing in germinal areas of the adult brain. Finally, we propose possible mechanisms of cancer initiation and progression and suggest a model of tumor initiation that includes intrinsic changes of resident NSC and potential changes in the microenvironment defining the niche where the NSC reside.

KW - Cancer

KW - Epigenetics

KW - Glioblastoma

KW - Proliferation

KW - Stem cells

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U2 - 10.1016/j.neuropharm.2009.12.019

DO - 10.1016/j.neuropharm.2009.12.019

M3 - Review article

C2 - 20045420

AN - SCOPUS:77649338990

SN - 0028-3908

VL - 58

SP - 903

EP - 910

JO - Neuropharmacology

JF - Neuropharmacology

IS - 6

ER -

Primary brain tumors, neural stem cell, and brain tumor cancer cells: Where is the link?

Abstract

Keywords

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