Primary atypical epithelial hyperplasia of prostate gland: a premalignant lesion?

Atypical primary hyperplasia (or dysplasia) of the prostate gland is based on both histological and cytological features. There are various histological forms which can consist of irregular epithelial proliferations demonstrating both tubular, papillary and/or pseudocribriform. They are almost always found in association with similar patterns of carcinoma. If they are found as the only lesion in a needle-biopsy of the prostate without the carcinoma then it is highly recommended that the patient be followed very carefully with subsequent biopsies.