Prevention of induced atherosclerosis by diversion of bile or blockade of intestinal lymphatics in dogs

P. J. Wilk; R. C. Karipineni; D. Pertsemlidis; C. A. Danese

doi:10.1097/00000658-197604000-00014

Prevention of induced atherosclerosis by diversion of bile or blockade of intestinal lymphatics in dogs

P. J. Wilk, R. C. Karipineni, D. Pertsemlidis, C. A. Danese

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Abstract

The prevention of induced hypercholesterolemia and atherosclerosis was studied by means of intestinal lymphatic blockade and of bile diversion in the dog. Hypercholesterolemia and atherosclerosis were produced by high cholesterol feeding after induction of hypothyroidism with radio iodine plus thiouracil. Complete diversion of bile, by shunting all bile into the urinary bladder, effectively prevented hypercholesterolemia and atherosclerosis; in contrast, blockade of the intestinal lymphatics failed to prevent the consequences of the atherogenic regimen, because of the development of collateral lymphatic channels.

Original language	English
Pages (from-to)	409-414
Number of pages	6
Journal	Annals of Surgery
Volume	183
Issue number	4
DOIs	https://doi.org/10.1097/00000658-197604000-00014
State	Published - 1976
Externally published	Yes

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abstract = "The prevention of induced hypercholesterolemia and atherosclerosis was studied by means of intestinal lymphatic blockade and of bile diversion in the dog. Hypercholesterolemia and atherosclerosis were produced by high cholesterol feeding after induction of hypothyroidism with radio iodine plus thiouracil. Complete diversion of bile, by shunting all bile into the urinary bladder, effectively prevented hypercholesterolemia and atherosclerosis; in contrast, blockade of the intestinal lymphatics failed to prevent the consequences of the atherogenic regimen, because of the development of collateral lymphatic channels.",

author = "Wilk, {P. J.} and Karipineni, {R. C.} and D. Pertsemlidis and Danese, {C. A.}",

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AU - Wilk, P. J.

AU - Karipineni, R. C.

AU - Pertsemlidis, D.

AU - Danese, C. A.

PY - 1976

Y1 - 1976

N2 - The prevention of induced hypercholesterolemia and atherosclerosis was studied by means of intestinal lymphatic blockade and of bile diversion in the dog. Hypercholesterolemia and atherosclerosis were produced by high cholesterol feeding after induction of hypothyroidism with radio iodine plus thiouracil. Complete diversion of bile, by shunting all bile into the urinary bladder, effectively prevented hypercholesterolemia and atherosclerosis; in contrast, blockade of the intestinal lymphatics failed to prevent the consequences of the atherogenic regimen, because of the development of collateral lymphatic channels.

AB - The prevention of induced hypercholesterolemia and atherosclerosis was studied by means of intestinal lymphatic blockade and of bile diversion in the dog. Hypercholesterolemia and atherosclerosis were produced by high cholesterol feeding after induction of hypothyroidism with radio iodine plus thiouracil. Complete diversion of bile, by shunting all bile into the urinary bladder, effectively prevented hypercholesterolemia and atherosclerosis; in contrast, blockade of the intestinal lymphatics failed to prevent the consequences of the atherogenic regimen, because of the development of collateral lymphatic channels.

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JO - Annals of Surgery

JF - Annals of Surgery

IS - 4

ER -

Prevention of induced atherosclerosis by diversion of bile or blockade of intestinal lymphatics in dogs

Abstract

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