TY - JOUR
T1 - Prevalent diabetes and risk of total, colorectal, prostate and breast cancers in an ageing population
T2 - meta-analysis of individual participant data from cohorts of the CHANCES consortium
AU - Amadou, Amina
AU - Freisling, Heinz
AU - Jenab, Mazda
AU - Tsilidis, Konstantinos K.
AU - Trichopoulou, Antonia
AU - Boffetta, Paolo
AU - Van Guelpen, Bethany
AU - Mokoroa, Olatz
AU - Wilsgaard, Tom
AU - Kee, Frank
AU - Schöttker, Ben
AU - Ordóñez-Mena, José M.
AU - Männistö, Satu
AU - Söderberg, Stefan
AU - Vermeulen, Roel C.H.
AU - Quirós, J. Ramón
AU - Liao, Linda M.
AU - Sinha, Rashmi
AU - Kuulasmaa, Kari
AU - Brenner, Hermann
AU - Romieu, Isabelle
N1 - Publisher Copyright:
© 2021, The Author(s), under exclusive licence to Cancer Research UK.
PY - 2021/5/25
Y1 - 2021/5/25
N2 - Background: We investigated whether associations between prevalent diabetes and cancer risk are pertinent to older adults and whether associations differ across subgroups of age, body weight status or levels of physical activity. Methods: We harmonised data from seven prospective cohort studies of older individuals in Europe and the United States participating in the CHANCES consortium. Cox proportional hazard regression was used to estimate the associations of prevalent diabetes with cancer risk (all cancers combined, and for colorectum, prostate and breast). We calculated summary risk estimates across cohorts using pooled analysis and random-effects meta-analysis. Results: A total of 667,916 individuals were included with an overall median (P25–P75) age at recruitment of 62.3 (57–67) years. During a median follow-up time of 10.5 years, 114,404 total cancer cases were ascertained. Diabetes was not associated with the risk of all cancers combined (hazard ratio (HR) = 0.94; 95% confidence interval (CI): 0.86–1.04; I2 = 63.3%). Diabetes was positively associated with colorectal cancer risk in men (HR = 1.17; 95% CI: 1.08–1.26; I2 = 0%) and a similar HR in women (1.13; 95% CI: 0.82–1.56; I2 = 46%), but with a confidence interval including the null. Diabetes was inversely associated with prostate cancer risk (HR = 0.81; 95% CI: 0.77–0.85; I2 = 0%), but not with postmenopausal breast cancer (HR = 0.96; 95% CI: 0.89–1.03; I2 = 0%). In exploratory subgroup analyses, diabetes was inversely associated with prostate cancer risk only in men with overweight or obesity. Conclusions: Prevalent diabetes was positively associated with colorectal cancer risk and inversely associated with prostate cancer risk in older Europeans and Americans.
AB - Background: We investigated whether associations between prevalent diabetes and cancer risk are pertinent to older adults and whether associations differ across subgroups of age, body weight status or levels of physical activity. Methods: We harmonised data from seven prospective cohort studies of older individuals in Europe and the United States participating in the CHANCES consortium. Cox proportional hazard regression was used to estimate the associations of prevalent diabetes with cancer risk (all cancers combined, and for colorectum, prostate and breast). We calculated summary risk estimates across cohorts using pooled analysis and random-effects meta-analysis. Results: A total of 667,916 individuals were included with an overall median (P25–P75) age at recruitment of 62.3 (57–67) years. During a median follow-up time of 10.5 years, 114,404 total cancer cases were ascertained. Diabetes was not associated with the risk of all cancers combined (hazard ratio (HR) = 0.94; 95% confidence interval (CI): 0.86–1.04; I2 = 63.3%). Diabetes was positively associated with colorectal cancer risk in men (HR = 1.17; 95% CI: 1.08–1.26; I2 = 0%) and a similar HR in women (1.13; 95% CI: 0.82–1.56; I2 = 46%), but with a confidence interval including the null. Diabetes was inversely associated with prostate cancer risk (HR = 0.81; 95% CI: 0.77–0.85; I2 = 0%), but not with postmenopausal breast cancer (HR = 0.96; 95% CI: 0.89–1.03; I2 = 0%). In exploratory subgroup analyses, diabetes was inversely associated with prostate cancer risk only in men with overweight or obesity. Conclusions: Prevalent diabetes was positively associated with colorectal cancer risk and inversely associated with prostate cancer risk in older Europeans and Americans.
UR - http://www.scopus.com/inward/record.url?scp=85103358096&partnerID=8YFLogxK
U2 - 10.1038/s41416-021-01347-4
DO - 10.1038/s41416-021-01347-4
M3 - Article
C2 - 33772152
AN - SCOPUS:85103358096
SN - 0007-0920
VL - 124
SP - 1882
EP - 1890
JO - British Journal of Cancer
JF - British Journal of Cancer
IS - 11
ER -