Prevalence of diverticulosis in recurrent Clostridium difficile infection

Michael J. Lipp, Odelya E. Pagovich, David Rabin, Albert D. Min, Brett B. Bernstein

Research output: Contribution to journalArticlepeer-review

4 Scopus citations

Abstract

AIM: To re-evaluate the theory that colonic diverticulosis is associated with relapse of Clostridium difficile associated disease (CDAD) in light of data suggesting increasing rates of CDAD infection and relapse. METHODS: Charts were reviewed for patients with recurrent CDAD who had also had a prior colonoscopy or flexible sigmoidoscopy. An age and gender matched control group was used to compare the prevalence of diverticulosis. RESULTS: Twenty-two patients met the study criteria, and the prevalence of diverticulosis in patients with CDAD relapse was 23% compared to 32% in age and sex matched controls (P = 0.44). A significant proportion of patients with CDAD relapse had comorbidities associated with immune suppression. CONCLUSION: Diverticulosis does not appear to be associated with CDAD relapse.

Original languageEnglish
Pages (from-to)345-347
Number of pages3
JournalWorld Journal of Gastroenterology
Volume16
Issue number3
DOIs
StatePublished - 21 Jan 2010
Externally publishedYes

Keywords

  • Clostridium difficile
  • Clostridium difficile associated disease
  • Diverticulosis
  • Immune suppression
  • Relapse

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