TY - JOUR
T1 - Prevalence of atrial fibrillation and cardiovascular risk factors in a 63-65 years old general population cohort
T2 - The Akershus Cardiac Examination (ACE) 1950 Study
AU - Berge, Trygve
AU - Lyngbakken, Magnus Nakrem
AU - Ihle-Hansen, Håkon
AU - Brynildsen, Jon
AU - Pervez, Mohammad Osman
AU - Aagaard, Erika Nerdrum
AU - Vigen, Thea
AU - Kvisvik, Brede
AU - Christophersen, Ingrid Elisabeth
AU - Steine, Kjetil
AU - Omland, Torbjørn
AU - Smith, Pål
AU - Røsjø, Helge
AU - Tveit, Arnljot
N1 - Publisher Copyright:
© Author(s) (or their employer(s)) 2018. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ.
PY - 2018/7/1
Y1 - 2018/7/1
N2 - Objectives To investigate the sex-specific prevalence of atrial fibrillation (AF), including subclinical AF found by screening in a general population aged 63-65 years. The prevalence of cardiovascular risk factors and their association with AF will also be investigated. Design Cross-sectional analysis of an observational, prospective, longitudinal, population-based cohort study. Setting General population in Akershus county, Norway. Participants Women and men born in 1950. We included 3706 of 5827 eligible individuals (63.6%); 48.8% were women. Methods All participants underwent extensive cardiovascular examinations, including 12-lead ECG. History of AF and other cardiovascular diseases were self-reported. Subsequent validation of all reported or detected AF diagnoses was performed. Results Mean age was 63.9±0.7 years. Prevalence of ECG-verified AF was 4.5% (women 2.4%, men 6.4%; p<0.001), including screen-detected AF in 0.3% (women 0.1%, men 0.6%; p<0.01). Hypertension was found in 62.0% (women 57.8%, men 66.0%; p<0.001). Overweight or obesity was found in 67.6% (women 59.8%, men 74.9%; p<0.001). By multivariate logistic regression, risk factors associated with AF were height (OR 1.67 per 10 cm; 95% CI 1.26 to 2.22; p<0.001), weight (OR 1.15 per 10 kg; 95% CI 1.01 to 1.30; p=0.03), hypertension (OR 2.49; 95% CI 1.61 to 3.86; p<0.001), heart failure (OR 3.51; 95% CI 1.71 to 7.24; p=0.001), reduced estimated glomerular filtration rate (OR 2.56; 95% CI 1.42 to 4.60; p<0.01) and at least one first-degree relative with AF (OR 2.32; 95% CI 1.63 to 3.31; p<0.001), whereas male sex was not significantly associated (OR 1.00; 95% CI 0.59 to 1.68; p=0.99). Conclusion In this cohort from the general population aged 63-65 years, we found a higher prevalence of known AF than previously reported below the age of 65 years. The additional yield of single time point screening for AF was low. Body size and comorbidity may explain most of the sex difference in AF prevalence at this age. Trial registration number NCT01555411; Results.
AB - Objectives To investigate the sex-specific prevalence of atrial fibrillation (AF), including subclinical AF found by screening in a general population aged 63-65 years. The prevalence of cardiovascular risk factors and their association with AF will also be investigated. Design Cross-sectional analysis of an observational, prospective, longitudinal, population-based cohort study. Setting General population in Akershus county, Norway. Participants Women and men born in 1950. We included 3706 of 5827 eligible individuals (63.6%); 48.8% were women. Methods All participants underwent extensive cardiovascular examinations, including 12-lead ECG. History of AF and other cardiovascular diseases were self-reported. Subsequent validation of all reported or detected AF diagnoses was performed. Results Mean age was 63.9±0.7 years. Prevalence of ECG-verified AF was 4.5% (women 2.4%, men 6.4%; p<0.001), including screen-detected AF in 0.3% (women 0.1%, men 0.6%; p<0.01). Hypertension was found in 62.0% (women 57.8%, men 66.0%; p<0.001). Overweight or obesity was found in 67.6% (women 59.8%, men 74.9%; p<0.001). By multivariate logistic regression, risk factors associated with AF were height (OR 1.67 per 10 cm; 95% CI 1.26 to 2.22; p<0.001), weight (OR 1.15 per 10 kg; 95% CI 1.01 to 1.30; p=0.03), hypertension (OR 2.49; 95% CI 1.61 to 3.86; p<0.001), heart failure (OR 3.51; 95% CI 1.71 to 7.24; p=0.001), reduced estimated glomerular filtration rate (OR 2.56; 95% CI 1.42 to 4.60; p<0.01) and at least one first-degree relative with AF (OR 2.32; 95% CI 1.63 to 3.31; p<0.001), whereas male sex was not significantly associated (OR 1.00; 95% CI 0.59 to 1.68; p=0.99). Conclusion In this cohort from the general population aged 63-65 years, we found a higher prevalence of known AF than previously reported below the age of 65 years. The additional yield of single time point screening for AF was low. Body size and comorbidity may explain most of the sex difference in AF prevalence at this age. Trial registration number NCT01555411; Results.
KW - atrial fibrillation
KW - cardiac epidemiology
KW - cardiovascular risk
KW - obesity
KW - prevalence
KW - screening
UR - http://www.scopus.com/inward/record.url?scp=85053068408&partnerID=8YFLogxK
U2 - 10.1136/bmjopen-2018-021704
DO - 10.1136/bmjopen-2018-021704
M3 - Article
C2 - 30068617
AN - SCOPUS:85053068408
SN - 2044-6055
VL - 8
JO - BMJ Open
JF - BMJ Open
IS - 7
M1 - e021704
ER -