Pretreatment weight status and weight loss among head and neck cancer patients receiving definitive concurrent chemoradiation therapy: Implications for nutrition integrated treatment pathways

Mary E. Platek; Elizabeth Myrick; Susan A. McCloskey; Vishal Gupta; Mary E. Reid; Gregory E. Wilding; David Cohan; Hassan Arshad; Nestor R. Rigual; Wesley L. Hicks; Maureen Sullivan; Graham W. Warren; Anurag K. Singh

doi:10.1007/s00520-013-1861-0

Pretreatment weight status and weight loss among head and neck cancer patients receiving definitive concurrent chemoradiation therapy: Implications for nutrition integrated treatment pathways

Mary E. Platek, Elizabeth Myrick, Susan A. McCloskey, Vishal Gupta, Mary E. Reid, Gregory E. Wilding, David Cohan, Hassan Arshad, Nestor R. Rigual, Wesley L. Hicks, Maureen Sullivan, Graham W. Warren, Anurag K. Singh

Research output: Contribution to journal › Article › peer-review

29 Scopus citations

Abstract

Purpose: The purpose was to examine the effect of pretreatment weight status on loco-regional progression for patients with squamous cell carcinoma of the head and neck (SCCHN) after receiving definitive concurrent chemoradiation therapy (CCRT). Methods: In an expanded cohort of 140 patients, we retrospectively reviewed weight status and loco-regional progression of SCCHN patients treated with CCRT between 2004 and 2010. Results: Pretreatment ideal body weight percentage (IBW%) was statistically significantly different for patients with disease progression than for those without progression (p = 0.02) but was not an independent predictor of progression. Median pretreatment IBW% was 118 (72-193) for the progression-free group and was 101.5 (73-163) for the group with progression. Both groups suffered clinically severe weight loss of approximately 9 % from baseline to end treatment. Conclusions: Pretreatment weight status, a very crude indicator of nutrition status, may have prognostic value in patients with SCCHN undergoing definitive CCRT. Inadequate nutritional status in these patients has been associated with poor clinical outcomes and decreased quality of life. Based on this report and others, the best next steps include routine validated malnutrition screening and the testing of evidence-based nutrition care protocols with the goals of minimizing weight loss and improvement of quality of life.

Original language	English
Pages (from-to)	2825-2833
Number of pages	9
Journal	Supportive Care in Cancer
Volume	21
Issue number	10
DOIs	https://doi.org/10.1007/s00520-013-1861-0
State	Published - Oct 2013
Externally published	Yes

Keywords

Head and neck cancer
Nutrition
Nutrition status
Quality of life
Radiation therapy
Weight loss

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10.1007/s00520-013-1861-0

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Platek, M. E., Myrick, E., McCloskey, S. A., Gupta, V., Reid, M. E., Wilding, G. E., Cohan, D., Arshad, H., Rigual, N. R., Hicks, W. L., Sullivan, M., Warren, G. W., & Singh, A. K. (2013). Pretreatment weight status and weight loss among head and neck cancer patients receiving definitive concurrent chemoradiation therapy: Implications for nutrition integrated treatment pathways. Supportive Care in Cancer, 21(10), 2825-2833. https://doi.org/10.1007/s00520-013-1861-0

@article{aabc4c0d28174f3c93b8f8b86c3d92c1,

title = "Pretreatment weight status and weight loss among head and neck cancer patients receiving definitive concurrent chemoradiation therapy: Implications for nutrition integrated treatment pathways",

abstract = "Purpose: The purpose was to examine the effect of pretreatment weight status on loco-regional progression for patients with squamous cell carcinoma of the head and neck (SCCHN) after receiving definitive concurrent chemoradiation therapy (CCRT). Methods: In an expanded cohort of 140 patients, we retrospectively reviewed weight status and loco-regional progression of SCCHN patients treated with CCRT between 2004 and 2010. Results: Pretreatment ideal body weight percentage (IBW%) was statistically significantly different for patients with disease progression than for those without progression (p = 0.02) but was not an independent predictor of progression. Median pretreatment IBW% was 118 (72-193) for the progression-free group and was 101.5 (73-163) for the group with progression. Both groups suffered clinically severe weight loss of approximately 9 % from baseline to end treatment. Conclusions: Pretreatment weight status, a very crude indicator of nutrition status, may have prognostic value in patients with SCCHN undergoing definitive CCRT. Inadequate nutritional status in these patients has been associated with poor clinical outcomes and decreased quality of life. Based on this report and others, the best next steps include routine validated malnutrition screening and the testing of evidence-based nutrition care protocols with the goals of minimizing weight loss and improvement of quality of life.",

keywords = "Head and neck cancer, Nutrition, Nutrition status, Quality of life, Radiation therapy, Weight loss",

author = "Platek, {Mary E.} and Elizabeth Myrick and McCloskey, {Susan A.} and Vishal Gupta and Reid, {Mary E.} and Wilding, {Gregory E.} and David Cohan and Hassan Arshad and Rigual, {Nestor R.} and Hicks, {Wesley L.} and Maureen Sullivan and Warren, {Graham W.} and Singh, {Anurag K.}",

note = "Funding Information: Acknowledgments This work was funded in part by the National Institutes of Health grant number R25CA114101.",

year = "2013",

month = oct,

doi = "10.1007/s00520-013-1861-0",

language = "English",

volume = "21",

pages = "2825--2833",

journal = "Supportive Care in Cancer",

issn = "0941-4355",

publisher = "Springer Verlag",

number = "10",

}

Platek, ME, Myrick, E, McCloskey, SA, Gupta, V, Reid, ME, Wilding, GE, Cohan, D, Arshad, H, Rigual, NR, Hicks, WL, Sullivan, M, Warren, GW & Singh, AK 2013, 'Pretreatment weight status and weight loss among head and neck cancer patients receiving definitive concurrent chemoradiation therapy: Implications for nutrition integrated treatment pathways', Supportive Care in Cancer, vol. 21, no. 10, pp. 2825-2833. https://doi.org/10.1007/s00520-013-1861-0

Pretreatment weight status and weight loss among head and neck cancer patients receiving definitive concurrent chemoradiation therapy: Implications for nutrition integrated treatment pathways. / Platek, Mary E.; Myrick, Elizabeth; McCloskey, Susan A. et al.
In: Supportive Care in Cancer, Vol. 21, No. 10, 10.2013, p. 2825-2833.

Research output: Contribution to journal › Article › peer-review

TY - JOUR

T1 - Pretreatment weight status and weight loss among head and neck cancer patients receiving definitive concurrent chemoradiation therapy

T2 - Implications for nutrition integrated treatment pathways

AU - Platek, Mary E.

AU - Myrick, Elizabeth

AU - McCloskey, Susan A.

AU - Gupta, Vishal

AU - Reid, Mary E.

AU - Wilding, Gregory E.

AU - Cohan, David

AU - Arshad, Hassan

AU - Rigual, Nestor R.

AU - Hicks, Wesley L.

AU - Sullivan, Maureen

AU - Warren, Graham W.

AU - Singh, Anurag K.

N1 - Funding Information: Acknowledgments This work was funded in part by the National Institutes of Health grant number R25CA114101.

PY - 2013/10

Y1 - 2013/10

N2 - Purpose: The purpose was to examine the effect of pretreatment weight status on loco-regional progression for patients with squamous cell carcinoma of the head and neck (SCCHN) after receiving definitive concurrent chemoradiation therapy (CCRT). Methods: In an expanded cohort of 140 patients, we retrospectively reviewed weight status and loco-regional progression of SCCHN patients treated with CCRT between 2004 and 2010. Results: Pretreatment ideal body weight percentage (IBW%) was statistically significantly different for patients with disease progression than for those without progression (p = 0.02) but was not an independent predictor of progression. Median pretreatment IBW% was 118 (72-193) for the progression-free group and was 101.5 (73-163) for the group with progression. Both groups suffered clinically severe weight loss of approximately 9 % from baseline to end treatment. Conclusions: Pretreatment weight status, a very crude indicator of nutrition status, may have prognostic value in patients with SCCHN undergoing definitive CCRT. Inadequate nutritional status in these patients has been associated with poor clinical outcomes and decreased quality of life. Based on this report and others, the best next steps include routine validated malnutrition screening and the testing of evidence-based nutrition care protocols with the goals of minimizing weight loss and improvement of quality of life.

AB - Purpose: The purpose was to examine the effect of pretreatment weight status on loco-regional progression for patients with squamous cell carcinoma of the head and neck (SCCHN) after receiving definitive concurrent chemoradiation therapy (CCRT). Methods: In an expanded cohort of 140 patients, we retrospectively reviewed weight status and loco-regional progression of SCCHN patients treated with CCRT between 2004 and 2010. Results: Pretreatment ideal body weight percentage (IBW%) was statistically significantly different for patients with disease progression than for those without progression (p = 0.02) but was not an independent predictor of progression. Median pretreatment IBW% was 118 (72-193) for the progression-free group and was 101.5 (73-163) for the group with progression. Both groups suffered clinically severe weight loss of approximately 9 % from baseline to end treatment. Conclusions: Pretreatment weight status, a very crude indicator of nutrition status, may have prognostic value in patients with SCCHN undergoing definitive CCRT. Inadequate nutritional status in these patients has been associated with poor clinical outcomes and decreased quality of life. Based on this report and others, the best next steps include routine validated malnutrition screening and the testing of evidence-based nutrition care protocols with the goals of minimizing weight loss and improvement of quality of life.

KW - Head and neck cancer

KW - Nutrition

KW - Nutrition status

KW - Quality of life

KW - Radiation therapy

KW - Weight loss

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U2 - 10.1007/s00520-013-1861-0

DO - 10.1007/s00520-013-1861-0

M3 - Article

C2 - 23743980

AN - SCOPUS:84884289015

SN - 0941-4355

VL - 21

SP - 2825

EP - 2833

JO - Supportive Care in Cancer

JF - Supportive Care in Cancer

IS - 10

ER -

Pretreatment weight status and weight loss among head and neck cancer patients receiving definitive concurrent chemoradiation therapy: Implications for nutrition integrated treatment pathways

Abstract

Keywords

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