Prestress due to dimensional changes caused by demineralization: A potential mechanism for microcracking in bone

Yener N. Yeni; Mitchell B. Schaffler; Gary Gibson; David P. Fyhrie

doi:10.1114/1.1451078

Prestress due to dimensional changes caused by demineralization: A potential mechanism for microcracking in bone

Yener N. Yeni, Mitchell B. Schaffler, Gary Gibson, David P. Fyhrie

Icahn School of Medicine at Mount Sinai

Research output: Contribution to journal › Article › peer-review

22 Scopus citations

Abstract

A series of experiments were carried out to gain more insight into mineralization-related strains in bone by studying the inverse problem of dimensional changes related to demineralization. Focus was on different anatomical orientations in miniaturized specimens of human and chemically altered bovine bone. Significant strains upon demineralization were observed. The strains indicate mechanisms of matrix expansion during mineralization consistent with observed in vivo microcracking patterns.

Original language	English
Pages (from-to)	217-225
Number of pages	9
Journal	Annals of Biomedical Engineering
Volume	30
Issue number	2
DOIs	https://doi.org/10.1114/1.1451078
State	Published - 2002

Keywords

Anisotropy
Collagen cross-linking
Cortical bone
Demineralization prestress
Glycation
Microcracking

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title = "Prestress due to dimensional changes caused by demineralization: A potential mechanism for microcracking in bone",

abstract = "A series of experiments were carried out to gain more insight into mineralization-related strains in bone by studying the inverse problem of dimensional changes related to demineralization. Focus was on different anatomical orientations in miniaturized specimens of human and chemically altered bovine bone. Significant strains upon demineralization were observed. The strains indicate mechanisms of matrix expansion during mineralization consistent with observed in vivo microcracking patterns.",

keywords = "Anisotropy, Collagen cross-linking, Cortical bone, Demineralization prestress, Glycation, Microcracking",

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KW - Collagen cross-linking

KW - Cortical bone

KW - Demineralization prestress

KW - Glycation

KW - Microcracking

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Prestress due to dimensional changes caused by demineralization: A potential mechanism for microcracking in bone

Abstract

Keywords

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