Pressure-Controlled Intermittent Coronary Sinus Occlusion: A Novel Approach to Improve Microvascular Flow and Reduce Infarct Size in STEMI

C. Michael Gibson, Issameddine Ajmi, Cajetan L. von Koenig, Mark A. Turco, Gregg W. Stone

Research output: Contribution to journalReview articlepeer-review

6 Scopus citations

Abstract

Despite successful primary percutaneous coronary intervention (PCI) for treatment of ST-segment elevation myocardial infarction (STEMI), myocardial salvage is frequently suboptimal resulting in large infarctions with increased rates of heart failure and death. Microvascular dysfunction after the procedure is frequently present and contributes directly to poor outcomes in STEMI. Pressure-controlled intermittent Coronary Sinus Occlusion (PiCSO) is a novel technology designed to mitigate microvascular dysfunction in STEMI. Non-randomized studies have suggested that PiCSO use during primary PCI in STEMI is safe, improves microvascular perfusion and reduces infarct size. Randomized trials are ongoing to investigate the safety and effectiveness of PiCSO in high-risk patients with anterior STEMI undergoing primary PCI.

Original languageEnglish
Pages (from-to)9-14
Number of pages6
JournalCardiovascular Revascularization Medicine
Volume45
DOIs
StatePublished - Dec 2022

Keywords

  • Microvascular dysfunction
  • Microvascular obstruction
  • PiCSO
  • Primary PCI
  • STEMI

Fingerprint

Dive into the research topics of 'Pressure-Controlled Intermittent Coronary Sinus Occlusion: A Novel Approach to Improve Microvascular Flow and Reduce Infarct Size in STEMI'. Together they form a unique fingerprint.

Cite this