@article{0ca690f6f9fc497bb31009351e8c4bdc,
title = "Preserved function of regulatory T cells in chronic HIV-1 infection despite decreased numbers in blood and tissue",
abstract = "Regulatory T cells (Tregs) are potent immune modulators, but their role in human immunodeficiency virus type 1 (HIV-1) pathogenesis remains poorly understood. We performed a detailed analysis of the frequency and function of Tregs in a large cohort of HIV-1-infected individuals and HIV-1 negative controls. While HIV {"}elite controllers{"} and uninfected individuals had similar Treg numbers and frequencies, the absolute numbers of Tregs declined in blood and gut-associated lymphoid tissue in patients with chronic progressive HIV-1 infection. Despite quantitative changes in Tregs, HIV-1 infection was not associated with an impairment of ex vivo suppressive function of flow-sorted Tregs in both HIV controllers and untreated chronic progressors.",
author = "Mathieu Angin and Kwon, \{Douglas S.\} and Hendrik Streeck and Fang Wen and Melanie King and Ashley Rezai and Kenneth Law and Hongo, \{Tomoyuki C.\} and Augustine Pyo and Alicja Piechocka-Trocha and Ildiko Toth and Florencia Pereyra and Musie Ghebremichael and Rodig, \{Scott J.\} and Milner, \{Danny A.\} and Richter, \{James M.\} and Marcus Altfeld and Kaufmann, \{Daniel E.\} and Walker, \{Bruce D.\} and Addo, \{Marylyn M.\}",
note = "Funding Information: Financial support. This study was funded with federal funds from the US National Institutes of Health (NIH) (grants NIAID [National Institute of Allergy and Infectious Diseases] KO8 AI074405 and AI074405-03S1 to M. M. A. and 1K08 AI084546-01 to D. K.). The work also received funding from the Elisabeth Glaser Pediatric AIDS Foundation (Pediatric HIV Vaccine Program award MV-00-9-900-1429-0-00 to M. M. A.), MGH/ECOR (Massachusetts General Hospital/Executive Committee on Research) (Physician Scientist Development Award to M. M. A.), and the Doris Duke Charitable Foundation (M. A.). The work was in part made possible with help from the Harvard University Center for AIDS Research, an NIH-funded program (P30 AI060354) supported by the following NIH cofund-ing and participating institutes and centers: NIAID, NCI (National Cancer Institute), NICHD (National Institute of Child Health and Human Development), NHLBI (National Heart, Lung, and Blood Institute), NIDA (National Institute on Drug Abuse), NIMH (National Institute of Mental Health), NIA (National Institute on Aging), NCCAM (National Center for Complementary and Alternative Medicine), FIC (Fogarty International Center), and OAR (Office of AIDS Research). Potential conflicts of interest. All authors: No reported conflicts.",
year = "2012",
month = may,
day = "15",
doi = "10.1093/infdis/jis236",
language = "English",
volume = "205",
pages = "1495--1500",
journal = "Journal of Infectious Diseases",
issn = "0022-1899",
publisher = "Oxford University Press",
number = "10",
}